TABLE 5.

Summary of convergent data

	Preclinical	Clinical	Comments
Exposure	Confirmed placental passage	Confirmed placental passage	In utero fetal exposure is likely similar to that in the mother.
	Confirmed presence in breast milk	Confirmed presence in breast milk	Exposure is substantially less but measurable. Physiologic significance not known but probably minimal.
Obstetrical outcome	Decreased birth weight	Decreased birth weight	The majority use weight as continuous variable and clinical significance is not clear.
Neonatal period	Increased motor activity/jitteriness	Increased motor activity/jitteriness	Limited to subgroup of the exposed offspring.
	Altered sleep architecture	Altered sleep architecture
Persistent pulmonary hypertension	Increased risk	Increased risk