TABLE 6.

Summary of nonconvergent data

	Preclinical	Clinical	Comments
Birth defects	No substantial evidence	Sporadic case reports and statistical evidence of increased risk in some large scale studies.	Numerous potential confounds in clinical literature preclude conclusions in the presence of prolonged record of antidepressant use during pregnancy (>40 years).
Long-term outcome	No persistent adverse effects	Limited studies from neonatal to early childhood do not demonstrate significant risk. No studies of long-term outcomes in offspring into adolescence or adulthood.	Preclinical studies of postnatal exposure reveal long term behavioral alterations, however many findings are not replicable. Clinical relevancy of dosing regimens must be taken into account.
Monoamine/neuroendocrine	Altered monoamine	Altered salivary cortisol in children	Preclinical studies may have questionable dosing relevancy
	Altered cortisol and insulin
Behavioral outcome	Some evidence for behavioral outcome	Some studies show behavioral differences in children	Preclinical studies of postnatal exposure reveal long term behavioral alterations
	Studies often conflicting or not replicated