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. 2014 Apr 2;9(4):e92205. doi: 10.1371/journal.pone.0092205

Table 1. Interrupted time-series analysis of LARC prescribing rates in general practices.

LARC (95% CI) Injectable (95% CI) Implant (95% CI) IUS (95% CI) IUCD (95% CI)
Time 0.99 (0.98,1.02) 0.98 (0.96,0.99) 1.64 (1.49,1.80) 1.19 (1.11,1.28) 1.04 (0.98,1.11)
QOF 0.99 (0.97, 1.02) 0.99 (0.96, 1.01) 1.20 (1.09, 1.32) 0.97 (0.90, 1.04) 1.02 (0.94, 1.10)
Time after QOF 1.04 (1.03, 1.06) 1.06 (1.04, 1.08) 1.34 (1.13, 1.58) 1.11 (0.97, 1.26) 0.99 (0.93, 1.05)
Seasonality
Apr-Jun
Jul-Sep 0.97 (0.96, 0.99) 0.98 (0.97, 0.99) 0.95 (0.91, 1.00) 0.93 (0.89, 0.96) 0.95 (0.90, 1.01)
Oct-Dec 0.97 (0.95, 0.98) 0.98 (0.96, 0.99) 0.93 (0.88, 0.98) 0.91 (0.88, 0.95) 0.94 (0.89, 1.00)
Jan-Mar 0.98 (0.96, 0.99) 0.98 (0.97, 1.00) 1.02 (0.97, 1.07) 0.94 (0.91, 0.98) 1.01 (0.95, 1.07)
Socioeconomic status
Quintile 1 (the most affluent)
Quintile 2 1.21 (1.05, 1.39) 1.30 (1.11, 1.51) 1.32 (1.08, 1.60) 1.02 (0.81, 1.29) 1.21 (0.91, 1.61)
Quintile 3 1.33 (1.14, 1.55) 1.49 (1.26, 1.75) 1.23 (0.98, 1.54) 0.75 (0.57, 0.97) 1.40 (1.01, 1.93)
Quintile 4 1.64 (1.40, 1.93) 1.81 (1.52, 2.16) 1.14 (0.91, 1.44) 0.65 (0.49, 0.85) 1.10 (0.79, 1.54)
Quintile 5 (the most deprived) 1.05 (0.88, 1.25) 1.04 (0.86, 1.25) 1.26 (0.96, 1.65) 0.43 (0.32, 0.59) 1.07 (0.74, 1.56)
Residence
Rural
Urban 0.77 (0.66, 0.91) 0.84 (0.71, 0.99) 0.43 (0.35, 0.54) 0.55 (0.42, 0.72) 0.45 (0.32, 0.63)
White British (%) 1.01 (1.00, 1.01) 1.01 (1.00, 1.01) 1.00 (1.00, 1.01) 1.01 (1.00, 1.01) 1.00 (0.99, 1.00)
Female GP in the Practice
Without Female GP
With Female GP 2.03 (1.82, 2.27) 1.81 (1.61, 2.04) 2.40 (1.95, 2.97) 1.81 (1.46, 2.25) 2.26 (1.76, 2.90)

Note: LARCs (Long-Acting Reversible Contraceptives), IUS (Intra-uterine system), IUCD (Intra-uterine copper devise).

Model also controlled for regional variables (Primary Care Trust dummy variables), results not shown.

As the linearity of the time trend was not met for implant and IUS outcomes, quadratic term for the time variable was added in the model.The beta coefficients are 0.91 (95% CI = 0.89, 0.94) for implant, and 0.97 (95% CI = 0.95, 0.99) for IUS.