Table 3. Risk estimates for the involvement of polymorphisms in COX-2/HPGD/SLCO2A1/ABCC4 genes in colorectal cancer onset stratified by sex, smoking habits and body mass index.

Gene	n	aOR	95%CI	P value	Pbootstrap
COX-2
rs689466 (AAvsGG)
Sex
Female	180	0.89	0.25–3.23	0.862	0.840
Male	313	3.34	1.23–9.09	0.018	0.004
Smoking habits
Never-smokers	213	0.63	0.13–3.08	0.564	0.429
Ever-smokers*	142	5.77	1.49–22.42	0.011	0.004
BMI (kg/m2)#
<25	59	3.63	0.20–64.59	0.381	0.071
≥25	182	2.41	0.72–8.07	0.154	0.123
HPGD
rs1346271 (GGvsGC)
Sex
Female	214	0.42	0.23–0.78	0.005	0.007
Male	401	0.86	0.55–1.33	0.487	0.500
Smoking habits
Never-smokers	271	0.88	0.51–1.51	0.644	0.613
Ever-smokers*	171	0.62	0.30–1.27	0.190	0.183
BMI (kg/m2)#
<25	69	0.57	0.19–1.69	0.312	0.312
≥25	234	0.69	0.40–1.19	0.185	0.186
rs1426945 (GGvsAA)
Sex
Female	140	1.20	0.52–2.79	0.672	0.677
Male	211	0.38	0.20–0.74	0.004	0.006
Smoking habits
Never-smokers	168	1.02	0.50–2.08	0.966	0.969
Ever-smokers*	101	0.83	0.31–2.21	0.705	0.730
BMI (kg/m2)#
<25	42	1.07	0.28–4.12	0.922	0.932
≥25	135	1.29	0.59–2.86	0.525	0.563
SLCO2A1
rs6439448 (CCvsCA)
Sex
Female	253	0.72	0.39–1.33	0.292	0.314
Male	433	0.66	0.41–1.07	0.094	0.082
Smoking habits
Never-smokers	302	0.72	0.41–1.28	0.269	0.265
Ever-smokers*	185	0.64	0.29–1.41	0.272	0.277
BMI (kg/m2)#
<25	79	1.04	0.34–3.13	0.95	0.947
≥25	258	0.75	0.42–1.34	0.34	0.312
rs7616492 (GGvsAA)
Sex
Female	135	1.60	0.72–3.58	0.250	0.254
Male	260	2.35	1.28–4.28	0.005	0.008
Smoking habits
Never-smokers	163	1.48	0.64–3.27	0.37	0.382
Ever-smokers*	119	1.27	0.51–3.19	0.60	0.628
BMI (kg/m2)#
<25	50	0.06	0.006–0.69	0.023	0.012
≥25	142	2.18	1.00–4.77	0.051	0.050
ABCC4
rs1751051 (TTvsAA)
Sex
Female	151	2.20	0.83–5.81	0.111	0.151
Male	269	1.70	0.91–3.16	0.096	0.100
Smoking habits
Never-smokers	179	2.32	1.05–5.13	0.037	0.033
Ever-smokers*	114	1.26	0.44–3.57	0.665	0.681
BMI (kg/m2)#
<25	46	3.57	0.39–32.52	0.260	0.114
≥25	157	1.82	0.86–3.89	0.120	0.145
rs1751031 (AAvsAG)
Sex
Female	249	0.51	0.28–0.94	0.030	0.031
Male	437	0.78	0.49–1.22	0.269	0.269
Smoking habits
Never-smokers	301	0.69	0.39–1.21	0.196	0.203
Ever-smokers*	193	0.76	0.38–1.52	0.439	0.454
BMI (kg/m2)#
<25	80	0.52	0.19–1.45	0.213	0.255
≥25	261	0.76	0.44–1.31	0.324	0.351

^aOdds ratio (OR) adjusted for age (categorical variable, using the global median age of 60 years as cutoff); CI, confidence interval; BMI, body mass index; ^#Categorization based on the cutoff defined by the world Health Organization for overweight people;

*Never- and former-smokers pooled together.

Statistical significant results are at bold.