Table 3. Risk estimates for the involvement of polymorphisms in COX-2/HPGD/SLCO2A1/ABCC4 genes in colorectal cancer onset stratified by sex, smoking habits and body mass index.
Gene | n | aOR | 95%CI | P value | Pbootstrap |
COX-2 | |||||
rs689466 (AAvsGG) | |||||
Sex | |||||
Female | 180 | 0.89 | 0.25–3.23 | 0.862 | 0.840 |
Male | 313 | 3.34 | 1.23–9.09 | 0.018 | 0.004 |
Smoking habits | |||||
Never-smokers | 213 | 0.63 | 0.13–3.08 | 0.564 | 0.429 |
Ever-smokers* | 142 | 5.77 | 1.49–22.42 | 0.011 | 0.004 |
BMI (kg/m2)# | |||||
<25 | 59 | 3.63 | 0.20–64.59 | 0.381 | 0.071 |
≥25 | 182 | 2.41 | 0.72–8.07 | 0.154 | 0.123 |
HPGD | |||||
rs1346271 (GGvsGC) | |||||
Sex | |||||
Female | 214 | 0.42 | 0.23–0.78 | 0.005 | 0.007 |
Male | 401 | 0.86 | 0.55–1.33 | 0.487 | 0.500 |
Smoking habits | |||||
Never-smokers | 271 | 0.88 | 0.51–1.51 | 0.644 | 0.613 |
Ever-smokers* | 171 | 0.62 | 0.30–1.27 | 0.190 | 0.183 |
BMI (kg/m2)# | |||||
<25 | 69 | 0.57 | 0.19–1.69 | 0.312 | 0.312 |
≥25 | 234 | 0.69 | 0.40–1.19 | 0.185 | 0.186 |
rs1426945 (GGvsAA) | |||||
Sex | |||||
Female | 140 | 1.20 | 0.52–2.79 | 0.672 | 0.677 |
Male | 211 | 0.38 | 0.20–0.74 | 0.004 | 0.006 |
Smoking habits | |||||
Never-smokers | 168 | 1.02 | 0.50–2.08 | 0.966 | 0.969 |
Ever-smokers* | 101 | 0.83 | 0.31–2.21 | 0.705 | 0.730 |
BMI (kg/m2)# | |||||
<25 | 42 | 1.07 | 0.28–4.12 | 0.922 | 0.932 |
≥25 | 135 | 1.29 | 0.59–2.86 | 0.525 | 0.563 |
SLCO2A1 | |||||
rs6439448 (CCvsCA) | |||||
Sex | |||||
Female | 253 | 0.72 | 0.39–1.33 | 0.292 | 0.314 |
Male | 433 | 0.66 | 0.41–1.07 | 0.094 | 0.082 |
Smoking habits | |||||
Never-smokers | 302 | 0.72 | 0.41–1.28 | 0.269 | 0.265 |
Ever-smokers* | 185 | 0.64 | 0.29–1.41 | 0.272 | 0.277 |
BMI (kg/m2)# | |||||
<25 | 79 | 1.04 | 0.34–3.13 | 0.95 | 0.947 |
≥25 | 258 | 0.75 | 0.42–1.34 | 0.34 | 0.312 |
rs7616492 (GGvsAA) | |||||
Sex | |||||
Female | 135 | 1.60 | 0.72–3.58 | 0.250 | 0.254 |
Male | 260 | 2.35 | 1.28–4.28 | 0.005 | 0.008 |
Smoking habits | |||||
Never-smokers | 163 | 1.48 | 0.64–3.27 | 0.37 | 0.382 |
Ever-smokers* | 119 | 1.27 | 0.51–3.19 | 0.60 | 0.628 |
BMI (kg/m2)# | |||||
<25 | 50 | 0.06 | 0.006–0.69 | 0.023 | 0.012 |
≥25 | 142 | 2.18 | 1.00–4.77 | 0.051 | 0.050 |
ABCC4 | |||||
rs1751051 (TTvsAA) | |||||
Sex | |||||
Female | 151 | 2.20 | 0.83–5.81 | 0.111 | 0.151 |
Male | 269 | 1.70 | 0.91–3.16 | 0.096 | 0.100 |
Smoking habits | |||||
Never-smokers | 179 | 2.32 | 1.05–5.13 | 0.037 | 0.033 |
Ever-smokers* | 114 | 1.26 | 0.44–3.57 | 0.665 | 0.681 |
BMI (kg/m2)# | |||||
<25 | 46 | 3.57 | 0.39–32.52 | 0.260 | 0.114 |
≥25 | 157 | 1.82 | 0.86–3.89 | 0.120 | 0.145 |
rs1751031 (AAvsAG) | |||||
Sex | |||||
Female | 249 | 0.51 | 0.28–0.94 | 0.030 | 0.031 |
Male | 437 | 0.78 | 0.49–1.22 | 0.269 | 0.269 |
Smoking habits | |||||
Never-smokers | 301 | 0.69 | 0.39–1.21 | 0.196 | 0.203 |
Ever-smokers* | 193 | 0.76 | 0.38–1.52 | 0.439 | 0.454 |
BMI (kg/m2)# | |||||
<25 | 80 | 0.52 | 0.19–1.45 | 0.213 | 0.255 |
≥25 | 261 | 0.76 | 0.44–1.31 | 0.324 | 0.351 |
Odds ratio (OR) adjusted for age (categorical variable, using the global median age of 60 years as cutoff); CI, confidence interval; BMI, body mass index; #Categorization based on the cutoff defined by the world Health Organization for overweight people;
*Never- and former-smokers pooled together.
Statistical significant results are at bold.