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. 2014 Apr 2;9(4):e90878. doi: 10.1371/journal.pone.0090878

Figure 1. gga-miR-375 expression was frequently downregulated in ALV-J induced cancer.

Figure 1

Liver lesions induced by viral infection in SPF white leghorn chickens at 70 days (A) and later (B). Representative histological features of nontumour liver and myeloma liver are shown with hematoxylin and eosin staining, 400× (B). (C) The miRNAs significantly associated with ALV-J by significance analysis of microarrays are listed. gga-miR-375 is most significantly associated with ALV-J infected liver tissue, as determined by significance analysis of microarrays. (D) Quantitative real-time PCR quantification of gga-miR-375 expression in the liver of ALV-J infected chickens every 10 days between 10 and 60 days post transfection (**P < 0.01, *p<0.05).