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. 2014 Mar 6;3(4):470–480. doi: 10.5966/sctm.2013-0038

Figure 1.

Figure 1.

CD271 is present in the SVZ of human elderly subjects and in SVZ neurospheres. Quantitative polymerase chain reaction was performed on neurospheres derived from human adult SVZ tissue, human adult SVZ tissue, and subcortical white matter derived from control donors for CD271 (A), GFAPδ (B), GFAPα (C), and nestin (D). Data are expressed as median and interquartile ranges. Analysis of significance was performed by Mann-Whitney U test. n = 4. Postmortem SVZ tissue sections obtained from elderly control subjects were stained for GFAPδ (E) or CD271 (F), and pictures were taken in the same SVZ areas to compare the staining pattern. CD271+ cells in the human adult SVZ are also immunopositive for GFAPδ (G, H), SOX2 (I, J), and nestin (K, L). Scale bar represents 100 μm (E–G, I, K), 10 μm (H), or 25 μm (J, L). Abbreviations: GFAP, glial fibrillary acidic protein; nd, not detectable; NES, nestin; SOX2, sex-determining region Y-box 2; SVZ, subventricular zone; WM, white matter.