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. 2014 Feb 20;3(4):458–469. doi: 10.5966/sctm.2013-0117

Figure 4.

Figure 4.

Quantitative reverse transcription-polymerase chain reaction characterization of multipotent human adult neural progenitor cells (aNPC) from white and hippocampal tissue. Gene expression analysis of marker genes for neural stem/progenitor cells (A), glial lineage-restricted cells (B), and neuronal restricted progenitor cells (C) in aNPC and fNSC during expansion using quantitative reverse transcription-polymerase chain reaction. One-way analysis of variance revealed statistical significant differences for SOX2 (F value: 6.6; p = .015), MSI1 (F value: 11.0; p = .004), MKI67 (F value: 20.4; p < .001), PDGFRα (F value: 35.4; p < .001), PAX6 (F value: 6.6; p = .025), and TUBIII (F value: 5.3; p = .040), but not for CD133 (F value: 0.2; p = .805), NESTIN (F value: 3.3; p = .086), CSPG4 (F value: 1.6; p = .248), OLIG2 (F value: 0.9; p = .437), GALC (F value: 1.1; p = .377), GFAP (F value: 3.4; p = .091), and SOX1 (F value: 152; p value <.0001). Results are mean values ± SEM from at least three independent experiments. ∗, p < .05; ∗∗, p < .01; ∗∗∗, p < .001 when compared with aNPCWM (post hoc Bonferroni adjusted t test). #, p < .05; ##, p < .01; ###, p < .001 when compared with aNPCHIP (post hoc Bonferroni adjusted t test). Abbreviations: aNPCHIP, hippocampal adult neural progenitor cell; aNPCWM, white matter adult neural progenitor cell; fNSC, fetal neural stem cell; GALC, galactocerebroside; GFAP, glial fibrillary acidic protein; HMBS, hydroxymethylbilane synthase; MSI1, Musashi1; OLIG2, oligodendrocyte transcription factor 2; PDGFR, platelet-derived growth factor receptor.