Figure 1.

A schematic representation of the different reprogramming strategies suggested for deriving cardiomyocytes for myocardial regeneration. These include the iPSC approach (top), the partial reprogramming strategy (middle), and the direct reprogramming strategy. The generated cardiomyocytes can be then engrafted into the failing heart. Note that the direct reprogramming strategy could also potentially be used with direct application of the cardiac reprogramming transcription factors into the heart. Abbreviations: CM, cardiomyocyte; iPSC, induced pluripotent stem cell.