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. 2014 Feb 20;3(4):481–488. doi: 10.5966/sctm.2013-0165

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Figure 1. — Regulation of JAM-A expression in MSC and JAM-A overexpression promoted MSC migration in vitro. (A): A high fluorescence signal was observed after gene transduction. Bright punctiform green fluorescence was observed in JAM-A^ov MSCs. In all images, magnification is ×100. (C): JAM-A mRNA levels were confirmed by real-time polymerase chain reaction 48 hours after gene transduction. Marked upregulation of JAM-A expression was detected in JAM-A^ov MSCs, whereas low levels of JAM-A expression were observed in JAM-A^kd MSCs. ∗∗, p < .01. (B, D): In vitro migration results showed that overexpression of JAM-A enhanced the migration of MSCs. JAM-A^ov MSCs significantly increased the number of migrating cells. In all images, magnification is ×100. ∗∗, p < .01. Abbreviations: GFP, green fluorescent protein; JAM-A, junctional adhesion molecule A; MSC, mesenchymal stem cell.