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. 2014 Feb 20;3(4):481–488. doi: 10.5966/sctm.2013-0165

Figure 2.

Figure 2.

JAM-A overexpression promoted hair formation in the skin of nude mice. Left column: hair formation in the skin of nude mice. The hair quality in the JAM-Aov MSC group of mice was better than the other groups. (A–C): The number of twisted hair follicles (HFs) in the JAM-Aov MSC group was decreased compared with other groups. A positive signal of mitochondria was observed in three groups. Scale bars = 200 μm (A–C). (A1, B1, C1): Hair diameter in the JAM-Aov MSC group was significantly greater than in the other groups. Meanwhile, on the horizontal plane of the HF in the JAM-Aov MSC group, the hair root is organized into concentric circles of cells from outer to inner. In the JAM-Akd MSC group, the graft could be observed clearly (C1, C2). (C): The funnel-shaped mouths of hair follicles in the skin of JAM-Akd MSC injection mice were ampliate. (A1, A2): JAM-Aov MSCs migrated to HF. (B1, B2): GFP MSCs migrated to HF. The graft could be observed clearly too. But the number of graft under the same amplification was more than in the JAM-Aov MSC group. Scale bars = 50 μm (A1, A2, B1, B2, C1, C2). Abbreviations: GFP, green fluorescent protein; JAM-A, junctional adhesion molecule A; MSC, mesenchymal stem cell.