Figure 7.

EPR monitoring of ^•NO and/or HNO release by liposome-encapsulated detection system (0.5 mM NN⁺, 0.5 mM IN⁺ and 5 mM hIN⁺). The kinetics of NN⁺ decay (A) and IN⁺ accumulation (B) were measured after initiation of ^•NO or/and HNO generation by addition of 18 μM PAPA NONOate (○), 11 μM AS (•), or PAPA NONOate and AS together (□). Solid lines in panels A and B represent linear fits yielding the rates of NN⁺ decay and IN⁺ accumulation presented in the Table 1. Panel C shows the dependences of Δ[IN⁺] on Δ[NN⁺] calculated from the data in panels A and B.