Figure 3. HnRNP L activates or represses alternative splicing in a position-dependent manner. (A) Number of hnRNP L crosslink sites around 3′ (-200 to +75) and 5′ splice sites (-75 to +200) of protein-coding genes is diagrammed, separately for alternative and constitutive splice sites (upper and middle panels, respectively). Below, alternative (green) and constitutive (black) splice sites are compared, plotted in smooth lines (lower panel). (B) Number of hnRNP L crosslink sites around 3′ (-300 to +75) and 5′ splice sites (-75 to +300) of hnRNP L-regulated exons, separately for activated (upper panel) and repressed exons (middle panel). Non-target exons were used as background (black smooth lines). In the lower panel, hnRNP L-activated (red) and -repressed exons (blue) exons are compared, plotted in smooth lines. Below, the positional information of hnRNP L binding and its correlation with activator/repressor function is schematically summarized.