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. 2014 Mar 19;15(1):27–33. doi: 10.4142/jvs.2014.15.1.27

Fig. 1.

Fig. 1

Immunohistochemistry specific for Ki67 in the dentate gyrus. Ki67-positive nuclei were detected in the subgranular zone of the dentate gyrus. The number of Ki67-immunoreactive nuclei was decreased in the LFD-RSG group compared to the LFD-Vehicle group. Ki67-positive nuclei were rarely seen in the HFD-Vehicle group unlike the LFD-Vehicle group. The number of Ki67-positive nuclei was significantly increased in the HFD-RSG group compared to the HFD-Vehicle group. (A) low-fat diet (LFD)-fed vehicle-treated group (LFD-Vehicle). (B) LFD-fed rosiglitazone (RSG)-treated group (LFD-RSG). (C) high-fat diet (HFD)-fed vehicle-treated group (HFD-Vehicle). (D) HFD-fed RSG-treated (HFD-RSG) groups. (E) Relative numbers of Ki67-immunoreactive nuclei in the LFD-Vehicle, LFD-RSG, HFD-Vehicle, and HFD-RSG groups (n = 7 per group; *p < 0.05, Vehicle versus RSG groups; †p < 0.05, LFD versus HFD groups). All data are expressed as the mean ± standard error of the mean (SEM). ML: molecular layer, GCL: granule cell layer, PoL: polymorphic layer. Scale bar = 50 µm.