Table 3.
SC |
IM |
|||||
---|---|---|---|---|---|---|
Normal (n = 11) | Obese (n = 11) | P Valueb | Normal (n = 11) | Obese (n = 11) | P Valueb | |
Cmax, mIU/mL | 142 (115–192) | 89 (58–123) | .02 | 291 (225–380) | 436 (246–526) | .31 |
AUC, mIU/h·mL | 4152 (3410–5395) | 2352 (1593–3655) | .009 | 9586 (5945–11 625) | 13 327 (7736–14 863) | .25 |
Average concentration, mIU/mL | 72 (59–96) | 34 (25–55) | .008 | 189 (96–220) | 277 (168–344) | .18 |
Proportion of women who reached Tmax by the 12-hour time point is expressed as a percentage; all other data are expressed as median (interquartile range).
P value comparing responses after either sc or im injection in normal vs obese women were calculated using Wilcoxon rank sum tests.