Table 2. Results of quantitative real time RT-PCR.
| Treatment options (group)
|
|||
|---|---|---|---|
| Sample collection | ATRA (1) | As2O3 (2) | ATRA/As2O3 (3) |
| Pretreatment | n = 19 | n = 18 | n = 20 |
| Median of copy number (range) | 4,595.6 (1,305.6-531,249) | 6,655.7 (1,777.2-681,692.1) | 5,155.3 (1,111.2-618,050) |
| After CR | n = 19 | n = 18 | n = 20 |
| Median of copy number (range) | 793.5 (37.5-26,680) | 286.3 (19.1-13,543)* | 177.3 (0.7-389.9)†‡ |
| Median of reduction fold (range) | 6.7 (1.1-1152.7) | 32.1 (2.4-993.5)§ | 118.9 (2.2-3,559.0)¶∥ |
| After consolidation | n = 14 | n = 11 | n = 14 |
| Median of copy number (range) | 71.6 (0.39-481.2) | 41.3 (0.39-362.5) | 15.2 (0.03-252.4)** |
| Median of reduction fold (range) | 369.5 (22.2-19683.4) | 521.3 (18.1-46899) | 800 (25.9-523008)††‡‡ |
*
, P = 0.013 vs. group 1; †, P = 0.0092 vs. group 1; ‡, P = 0.041 vs. group 2; §, P = 0.0001 vs. group 1; ¶, P = 0.0001 vs. group 1; ∥, P = 0.0079 vs. group 2; **, P = 0.0489 vs. group 1; ††, P = 0.018 vs. group 1; ‡‡, P = 0.036 vs. group 2.