Table 4. Changes of bone marrow hematology and TUNEL-positive cells in APL patients.
| Treatment options (group)
|
Time after treatment, days
|
||||
|---|---|---|---|---|---|
| Cells | 0 | 13-16 | 19-23 | 30-35 | |
| ATRA (1) | |||||
| TUNEL-positive cells, % | 0 | 1.0 ± 0.5 | 0.5 ± 0.5 | 1.5 ± 1.0 | |
| Cell type, % | |||||
| Myeloblast | 2.6 ± 1.6 | 0.5 ± 0.5 | 0.5 | 2.3 ± 1.8 | |
| Promyelocyte | 81.2 ± 11.4 | 9.8 ± 3.5 | 6.2 ± 6.4 | 6 ± 4.6 | |
| Myelocyte | 4.5 ± 2.2 | 27.7 ± 6.9 | 27.3 ± 15.6 | 11 ± 8.0 | |
| Metamyelocyte | 1.2 ± 0.8 | 20.8 ± 5.3 | 16.3 ± 11.0 | 10.5 ± 7.5 | |
| Band | 1.2 ± 0.8 | 3.5 ± 2.1 | 7.3 ± 2.4 | 10.2 ± 4.0 | |
| Segmented | 4.5 ± 2.8 | 9 ± 5.8 | 12.3 ± 10.8 | ||
| Erythroid lineage | 3.5 ± 2.4 | 27.5 ± 11.5 | 21 ± 15.7 | 30.7 ± 5.9 | |
| Lymphoid lineage | 4.6 ± 1.5 | 7 ± 5.6 | 8.8 ± 9.4 | 9.3 ± 7.1 | |
| As2O3 (2) | |||||
| TUNEL-positive cells, % | 0 | 6.8 ± 2.2* | 12.6 ± 3.7† | 0.5 ± 0.5 | |
| Cell type, % | |||||
| Myeloblast | 3.0 ± 1.5 | 0.5 | 1 ± 0.7 | 0.7 ± 0.3 | |
| Promyelocyte | 78.2 ± 9.7 | 8.7 ± 6.1 | 4.3 ± 2.2 | 3.6 ± 1.8 | |
| Myelocyte | 5.4 ± 2.7 | 18.5 ± 5.2 | 19.3 ± 2.2 | 11.8 ± 4.7 | |
| Metamyelocyte | 2.5 ± 1.4 | 11.5 ± 6.1 | 13.4 ± 4.4 | 8.2 ± 3.6 | |
| Band | 0.6 ± 0.5 | 8.5 ± 3.1 | 14.6 ± 4.8 | 12.2 ± 3.1 | |
| Segmented | 3.2 ± 1.3 | 13.4 ± 4.9 | 11.4 ± 9.5 | ||
| Erythroid lineage | 4.5 ± 3.2 | 28.7 ± 4.3 | 25.3 ± 6.1 | 29.6 ± 10.6 | |
| Lymphoid lineage | 3.8 ± 2.2 | 14.2 ± 6.2 | 10.4 ± 6.1 | 15.6 ± 6.1 | |
| ATRA/As2O3 (3) | |||||
| TUNEL-positive cells, % | 0 | 16.3 ± 4.3‡§ | 25.4 ± 4.1¶∥ | 0.8 ± 0.5 | |
| Cell type, % | |||||
| Myeloblast | 2.8 ± 1.4 | 2.6 ± 2.0 | 0.5 | 1 ± 0.4 | |
| Promyelocyte | 82.8 ± 9.1 | 6.3 ± 6.1 | 2.8 ± 1.8 | 3 ± 0.7 | |
| Myelocyte | 3.8 ± 1.5 | 33.9 ± 11.7 | 6.8 ± 1.8 | 10.3 ± 4.2 | |
| Metamyelocyte | 2.0 ± 0.8 | 19.5 ± 10.8 | 21 ± 20.8 | 9.4 ± 4.8 | |
| Band | 1.0 ± 0.8 | 4.3 ± 3.4 | 13.5 ± 6.3 | 12.9 ± 2.9 | |
| Segmented | 7.9 ± 8.9 | 6.7 ± 2.1 | 14.6 ± 2.8 | ||
| Erythroid lineage | 2.2 ± 1.2 | 12.4 ± 9.4 | 36.8 ± 34.4 | 27.8 ± 3.5 | |
| Lymphoid lineage | 5.5 ± 3.6 | 8.4 ± 3.1 | 11.5 ± 9.3 | 16.2 ± 2.4 | |
*
, P = 0.034 vs. group 1; †, P = 0.001 vs. group 1; ‡, P < 0.0001 vs. group 1; §, P = 0.036 vs. group 2; ¶, P < 0.0001 vs. group 1; ∥, P = 0.021 vs. group 2.