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. 2004 Feb 12;101(15):5339–5346. doi: 10.1073/pnas.0308709101

Fig. 6.

Fig. 6.

Phase and period maps of SCN-lesioned mice. (A) (Top) Phase map of peripheral oscillators in mPer2Luc LD control mice (n = 8). (Middle) Phase map of peripheral oscillators in mPer2Luc DD control mice (n = 8). Arrows represent activity onset for each animal. (Bottom) Phase map of peripheral oscillators in mPer2Luc SCN-lesioned mice (n = 11). The average times (± SEM) of peaks were plotted against the time of last lights on. Each animal is represented by a colored symbol, and tissues from the same animal are connected by lines. Circles represent 12 and 16 days in DD; squares represent 32 days in DD. (B) Circadian period values of mPER2::LUC rhythms in LD control mice (○), DD control mice (•), and SCN-lesioned mice (▴). Mean periods (± SEM) for cornea, liver, pituitary, kidney, and lung are shown. (C) Superimposed plots of bioluminescent data from pituitary and lung for all animals including LD controls, DD controls, and SCN-lesioned mice. The first three cycles in culture are represented; each animal's record is of a different color. Phase desynchronization is evident in individual records of the SCN-lesioned animals for both tissues.