Table 2.
rs4606 and risk of hypertension (SBP ≥ 140 mmHg/DBP ≥ 90 mmHg and/or taking antihypertensive drugs) according to obstetric history
| |
Unadjusted |
Age-adjusted |
Age and BMI-adjusted |
||||||
|---|---|---|---|---|---|---|---|---|---|
| Obstetric history group | OR (95% CI) † | P | Number included in analysis (n) | OR (95% CI) † | P | Number included in analysis (n) | OR (95% CI) † | P | Number included in analysis (n) |
|
Preeclampsia + control |
CG: 1.07 (0.90-1.27) |
0.451 |
2945 |
CG: 1.10 (0.91-1.33) |
0.321 |
2945 |
CG: 1.12 (0.92-1.36) |
0.254 |
2937 |
| GG: 1.23 (0.90-1.67) |
0.193 |
GG: 1.41 (1.01-1.97) |
0.047* |
GG: 1.49 (1.05-2.11) |
0.027* |
||||
|
Control |
CG: 0.998 (0.80-1.25) |
0.989 |
2012 |
CG: 1.07 (0.84-1.36) |
0.604 |
2012 |
CG: 1.07 (0.83-1.38) |
0.595 |
2007 |
| GG: 1.02 (0.68-1.54) |
0.923 |
GG: 1.23 (0.78-1.92) |
0.369 |
GG: 1.28 (0.80-2.04) |
0.303 |
||||
|
Preeclampsia |
CG: 1.07 (0.81-1.41) |
0.653 |
933 |
CG: 0.98 (0.72-1.33) |
0.897 |
933 |
CG: 1.03 (0.76-1.41) |
0.838 |
930 |
| GG: 1.53 (0.93-2.52) |
0.094 |
GG: 1.61 (0.93-2.80) |
0.091 |
GG: 1.76 (1.00-3.11) |
0.052 |
||||
|
Early-onset preeclampsia |
CG: 3.30 (0.87-12.5) |
0.079 |
50 |
CG: 4.50 (0.93-21.9) |
0.062 |
50 |
CG: 7.90 (1.30-48.2) |
0.025* |
50 |
| CG/GG: 3.38 (0.90-12.6)‡ |
0.070 |
CG/GG: 4.68 (0.98-22.3)‡ |
0.053 |
CG/GG: 7.96 (1.33-47.8)‡ |
0.023* |
||||
|
Later onset preeclampsia |
CG: 1.01 (0.76-1.34) |
0.946 |
883 |
CG: 0.913 (0.67-1.25) |
0.570 |
883 |
CG: 0.95 (0.69-1.31) |
0.761 |
880 |
| GG: 1.47 (0.88-2.43) |
0.139 |
GG: 1.53 (0.87-2.68) |
0.137 |
GG: 1.68 (0.94-2.98) |
0.079 |
||||
|
Recurrent preeclampsia |
CG: 1.98 (0.98-4.01) |
0.058 |
158 |
CG: 1.73 (0.84-3.58) |
0.139 |
158 |
CG: 1.66 (0.79-3.49) |
0.183 |
158 |
| CG/GG: 2.04 (1.03-4.03)ǂ |
0.040* |
CG/GG: 1.78 (0.89-3.59)ǂ |
0.106 |
CG/GG: 1.81 (0.88-3.71)ǂ |
0.105 |
||||
| Non-recurrent preeclampsia | CG: 0.95 (0.70-1.29) |
0.747 |
775 | CG: 0.871 (0.62-1.23) |
0.428 |
775 | CG: 0.94 (0.66-1.33) |
0.710 |
772 |
| GG: 1.43 (0.82-2.49) | 0.212 | GG: 1.58 (0.84-2.98) | 0.159 | GG: 1.62 (0.85-3.12) | 0.145 | ||||
*Statistically significant P < 0.05. SBP: Systolic blood pressure. DBP: Diastolic blood pressure. †Reference genotype: CC. ‡Merging of CG + GG genotype (n = 28) due to low numbers in GG genotype group (n = 2).
ǂMerging of CG + GG genotype (n = 91) due to low numbers in GG genotype group (n = 15). Non-recurrent preeclampsia: primiparas and multiparas with only one preeclamptic pregnancy.