Figure 5.

ATL (15-epi-lipoxin A₄) formation in lung homogenates is COX-2 dependent. In lung homogenates from WT mice, administration of aspirin (100 mg/kg) and LPS (10 mg/kg) but neither on its own, produced an increase in ATL levels (A) but not LXA₄ levels (B). This effect was abolished by deletion of COX-2 or COX-1. In the same animals, ATL levels in plasma were not altered by any treatment or COX-1/2 deletion (C). Data are the means ± se for tissue from n = 6 mice aged 10–12 wk. Data were analyzed using 1-way ANOVA followed by Bonferroni's multiple comparison test. *P < 0.05.