Table 2.

Genetic association between I_SA subunits and disease/disorders.

Subunit	Phenotype	Subject	Conclusion and analysis method	Reference
Kv4.2	Temporal lobe epilepsy	Human-Japanese	Yes: electrophysiology	Singh et al. (2006)
KChIP	Ventricular tachycardia	Mouse	Yes: KChIP2 knockout	Kuo et al. (2001)
	Pain	Mouse	Yes: KChIP3 knockout	Cheng et al. (2002)
DPP6	Amyotrophic lateral sclerosis	Human-multi-ethnic	Inconsistent: GWAS analysis SNP analysis CNV association	Cronin et al. (2008), van Es et al. (2008), Chio et al. (2009), Li et al. (2009), Blauw et al. (2010), Fogh et al. (2011)
	Progressive multiple sclerosis	Human-Italian	Yes: SNP analysis	Brambilla et al. (2012)
	Tardive dyskinesia schizophrenia	Human-Japanese	Yes: GWAS analysis	Tanaka et al. (2013)
	Autism spectrum disorder	Human-multi-ethnic	Yes: ID mutations CNV association	Marshall et al. (2008), Noor et al. (2010)
	Microcephaly	Human-Chinese	Yes: CNV association	Liao et al. (2013)
DPP10	Asthma	Human-multi-ethnic	Yes: SNP association GWAS analysis Positional cloning	Allen et al. (2003), Zhou et al. (2009), Wu et al. (2010), Torgerson et al. (2012)
	Autism spectrum disorder	Human-mixed	Yes: CNV analysis	Girirajan et al. (2013)
	Bipolar disorder schizophrenia	Human-Norwegian	Yes: GWAS analysis	Djurovic et al. (2010)

GWAS, genome-wide association studies; CNV, copy-number variants; SNP, single-nucleotide polymorphism.