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. 2014 Mar 27;8:90. doi: 10.3389/fncel.2014.00090

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Copyright © 2014 Seseña, Vega and Soto.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The voltage-dependent signaling mechanism did not participate in the inhibition of the I_Ca by MOR activation. (A,B) Traces of the I_Ca under the control condition and after 1 μM DAMGO perfusion. Protocols to evaluate the voltage-dependent modulation of the I_Ca consisted of two depolarizing pulses (P₁ and P₂, to −10 mV) separated by a depolarizing pulse that acted as a P₂ prepulse (to 80 mV). (B) Bar graph showing the value of the P2/P1 ratio under control and after DAMGO. (C) The time between P₁ and the pulse to 80 mV was 1 s to avoid inactivation accumulation. The ratio P₂/P₁ did not change between the control and after DAMGO application, independent of the time between P₁ and the pulse to 80 mV. (D) Bar graph showing the value of the P2/P1 ratio under control and after DAMGO.