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. 2013 Dec 27;23(6):3049–3064. doi: 10.1007/s00044-013-0890-z

Table 4.

Anticancer activity (% cytotoxicity) and CTC50 values of synthesized compounds on BT474 (breast cancer cell line)

Treatment % cytotoxicity (100 − % cell survival) of BT474 cell line at conc. (μM) CTC50 (μM)a
100 33.33 11.11 3.7 1.23 0.41 0.13 0.045 0.015 0.005
Log conc.
2.00 1.52 1.05 0.57 0.09 −0.39 −0.89 −1.35 −1.82 −2.30
4a 28.73 28.11 27.45 26.28 25.92 25.37 24.64 23.12 22.64 20.06 61.336
4b 26.66 23.31 22.19 20.47 19.85 18.14 17.99 17.37 16.56 16.18 5.496
4c 41.35 40.32 39.37 38.82 37.56 36.26 35.55 34.19 32.11 30.65 8.743
4d 32.09 30.34 29.44 28.10 27.13 26.82 26.23 25.34 24.24 23.19 1.746
4e 40.37 38.91 37.21 36.96 35.73 33.14 32.29 31.76 31.02 30.89 2.798
4f 59.31 55.26 52.38 50.12 48.54 45.32 43.76 41.28 39.05 37.60 1.561
4g 38.22 37.84 36.21 35.19 34.87 34.15 33.18 32.07 31.45 30.59 2.346
6a 32.69 32.09 31.26 30.89 30.38 29.83 28.61 27.96 27.18 26.01 11.147
6b 31.97 30.32 29.34 28.72 28.14 27.13 26.25 25.78 25.06 24.32 3.656
6c 39.44 38.21 37.91 37.09 36.69 35.37 34.95 34.13 33.27 33.11 11.552
6d 33.85 33.29 32.92 32.11 31.02 30.56 29.44 28.93 27.72 26.34 127.620
6e 37.27 34.77 32.45 31.08 30.13 29.38 28.67 28.11 28.01 27.14 2.418
6f 50.81 45.31 42.19 40.62 37.19 35.84 33.41 32.15 30.07 29.13 1.007
6g 46.38 44.19 42.44 39.51 38.20 37.56 34.12 33.86 32.75 30.46 1.028
7a 46.32 43.67 41.82 40.72 39.54 38.21 37.77 36.69 34.95 34.13 9.215
7b 36.61 35.52 34.59 33.33 32.16 31.36 30.24 29.47 28.13 27.42 1.884
7c 27.87 26.43 25.71 24.22 22.81 20.98 20.13 19.76 19.43 18.80 10.336
7d 38.89 37.95 36.07 35.68 34.42 33.11 31.92 30.64 29.31 28.53 1.195
7e 51.16 50.38 49.11 48.46 47.56 47.13 46.28 45.39 44.21 43.90 2.349
7f 64.14 60.28 58.64 56.72 54.23 52.17 50.09 47.21 45.80 42.38 0.751
7g 40.06 38.46 37.71 34.74 33.24 32.73 31.29 29.98 28.39 27.27 1.473
9a 65.97 41.46 40.56 40.2 38.97 38.05 37.05 36.38 35.84 35.26 13.723
9b 64.99 62.26 60.68 56.34 50.12 46.10 42.01 41.47 39.42 38.81 2.414
9c 67.11 58.80 54.83 53.61 50.42 47.02 44.37 42.60 41.45 38.13 0.794
9d 39.40 38.00 37.37 36.80 36.75 34.22 33.96 33.52 33.42 33.28 11.557
9e 56.21 47.52 41.77 37.86 31.92 29.89 28.93 27.27 26.43 25.17 12.770
9f 38.66 38.22 36.12 35.80 35.51 34.78 34.75 33.86 32.57 30.64 112.202
9g 38.14 36.17 34.74 33.23 32.82 31.42 29.23 28.71 28.02 27.38 18.345
9h 47.67 41.55 38.42 35.17 34.21 33.76 32.92 30.64 29.11 29.02 1.281
9i 41.29 40.50 39.19 37.56 36.73 36.12 35.42 34.59 33.31 31.52 6.324
9j 61.43 56.93 52.13 49.34 45.14 43.57 40.13 37.35 34.64 30.38 1.361
ISL 73.52 66.14 62.46 54.71 52.94 50.79 49.03 46.42 44.97 42.23 0.348

aCTC50 cytotoxicity concentration (μM) determined experimentally