Table 5.

Anticancer activity (% cytotoxicity) and CTC₅₀ values of synthesized compounds on NCI-H226 (lung cancer cell line)

Treatment	% Cytotoxicity (100 − % cell survival) of NCI-H226 cell line at conc. (μM)										CTC50 (μM)a
	100	33.33	11.11	3.7	1.23	0.41	0.13	0.045	0.015	0.005
	Log conc.
	2.00	1.52	1.05	0.57	0.09	−0.39	−0.89	−1.35	−1.82	−2.30
4a	27.86	27.49	27.09	26.55	26.13	25.46	24.94	24.22	23.14	22.41	145.347
4b	39.46	37.21	36.30	35.96	35.11	34.69	34.05	33.46	32.87	32.12	33.268
4c	54.16	51.24	49.12	47.20	45.35	42.21	39.29	38.91	38.19	37.65	2.527
4d	42.56	42.06	39.73	38.26	38.02	37.34	36.29	35.23	35.11	34.16	17.482
4e	34.59	33.33	32.16	31.26	30.59	29.89	29.55	28.93	28.11	27.31	7.965
4f	52.87	50.14	48.31	46.52	45.78	42.90	41.57	39.72	38.63	37.24	1.197
4g	41.75	41.35	40.29	39.37	38.14	37.84	37.13	36.95	36.10	35.77	22.274
6a	40.92	38.89	38.22	36.05	35.61	33.65	32.94	32.17	31.57	30.46	52.953
6b	49.15	47.06	45.27	43.36	42.66	41.98	39.12	38.44	37.26	36.29	1.119
6c	38.98	38.32	36.52	35.08	34.91	34.79	34.15	33.59	32.75	30.41	12.829
6d	49.15	47.26	45.31	43.41	41.96	41.18	39.12	37.05	36.38	35.51	1.816
6e	54.52	51.14	50.83	49.22	48.64	47.65	45.39	42.38	41.25	38.76	1.018
6f	65.97	59.62	57.09	55.18	54.64	51.26	48.28	46.54	44.85	41.28	0.978
6g	46.01	43.19	42.63	41.32	40.65	39.82	37.34	36.75	34.95	33.52	3.108
7a	36.94	36.21	35.13	34.55	32.17	30.41	29.35	29.17	28.36	27.44	10.735
7b	42.44	41.12	40.65	39.07	38.79	37.41	37.05	35.48	33.62	33.48	13.829
7c	40.27	38.88	38.60	38.21	38.04	37.79	36.59	34.75	34.03	33.23	1.164
7d	38.92	38.50	37.91	35.98	35.37	35.66	35.17	34.59	34.13	33.72	6.342
7e	36.05	35.80	35.53	34.87	34.52	33.48	31.75	30.46	29.97	29.04	12.729
7f	67.99	65.83	60.68	56.43	52.12	46.10	42.62	40.07	39.26	38.76	1.784
7g	38.99	38.74	37.12	36.26	36.11	35.72	35.32	33.62	32.79	30.66	10.215
9a	42.36	41.13	39.07	38.10	37.89	37.01	36.15	35.32	34.84	33.29	5.674
9b	37.99	37.72	37.02	36.62	36.47	36.11	35.72	35.43	29.46	27.75	1.487
9c	43.51	40.34	38.19	37.73	36.15	35.87	35.12	34.15	33.25	31.49	5.726
9d	53.02	48.22	47.78	43.14	41.21	40.59	38.31	37.46	36.27	35.65	2.268
9e	51.36	49.32	48.22	47.61	45.79	43.35	42.54	41.86	40.27	39.11	12.763
9f	40.39	38.72	37.14	36.91	35.67	34.95	33.42	32.39	31.24	30.26	17.327
9g	42.47	39.75	39.20	38.61	37.51	36.33	35.06	34.11	33.17	32.72	166.376
9h	39.98	39.25	37.94	37.46	37.24	36.39	36.32	35.35	35.01	32.85	1.467
9i	38.66	38.57	36.72	35.27	34.95	34.59	34.14	33.97	33.92	33.61	9.215
9j	52.43	45.35	42.72	39.13	37.04	36.06	35.27	34.62	33.23	32.98	0.913
ISL	59.26	44.69	38.58	36.46	34.12	32.98	31.11	30.20	28.42	26.37	0.313

^aCTC₅₀ cytotoxicity concentration (μM) determined experimentally