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. 2014 Mar 7;15:73. doi: 10.1186/1745-6215-15-73

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Copyright © 2014 Broglio et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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The symbols use in all panels refer to the prior weights indicated in Figure1,’ Abbreviations s, simple; p, pessimistic; o, optimistic; m, moderate; and c, custom. The top five lines and right y-axis show the futility results. The bottom five lines and the left y-axis show the success results. (A) Predictive probability of success or futility at or before the indicated interim analysis. (B) Probability of success or futility at the indicated interim analysis conditionally on ‘Continue’ at the previous interim analysis. (C) Predictive probability of eventual success or futility assuming ‘Continue’ at the previous interim analysis.