Table 3.
Results of sensitivity analyses: multivariable logistic regression models of the association between Normocapnia (defined as partial pressure of arterial carbon dioxide 31 to 49 mmHg) on initial post-resuscitation arterial blood gas, and good neurological function (defined as Cerebral Performance Category 1 or 2) at hospital discharge
| Variable | Beta | Standard error | Odds Ratio | 95% LCI | 95% UCI | P -value |
|---|---|---|---|---|---|---|
| Normocapnia |
1.51 |
0.62 |
4.54 |
1.34 |
15.35 |
0.01 |
| PEA/asystole initial rhythm |
-0.65 |
0.58 |
0.52 |
0.17 |
1.63 |
0.26 |
| Variable |
Beta |
Standard Error |
Odds Ratio |
95% LCI |
95% UCI |
P-value |
| Normocapnia |
1.50 |
0.62 |
4.50 |
1.33 |
15.15 |
0.02 |
| CPR > 20 minutes |
-0.34 |
0.89 |
0.71 |
0.13 |
4.06 |
0.70 |
| Variable |
Beta |
Standard Error |
Odds Ratio |
95% LCI |
95% UCI |
P-value |
| Normocapnia |
1.24 |
0.63 |
3.46 |
1.01 |
11.89 |
0.04 |
| Post-resuscitation shocka |
-2.16 |
1.14 |
0.11 |
0.01 |
1.08 |
0.05 |
| Variable |
Beta |
Standard Error |
Odds Ratio |
95% LCI |
95% UCI |
P-value |
| Normocapnia |
1.36 |
0.63 |
3.89 |
1.14 |
13.26 |
0.03 |
| Metabolic acidosisb |
-0.76 |
0.54 |
0.47 |
0.16 |
1.34 |
0.16 |
| Variable |
Beta |
Standard Error |
Odds Ratio |
95% LCI |
95% UCI |
P-value |
| Normocapnia |
1.56 |
0.63 |
4.76 |
1.39 |
16.28 |
0.01 |
| Age (decile) |
-0.23 |
0.16 |
0.79 |
0.58 |
1.09 |
0.15 |
| Variable |
Beta |
Standard Error |
Odds Ratio |
95% LCI |
95% UCI |
P-value |
| Normocapnia |
1.49 |
0.62 |
4.44 |
1.31 |
15.11 |
0.02 |
| Charlson comorbidity index |
-0.44 |
0.28 |
0.64 |
0.37 |
1.10 |
0.11 |
| Variable |
Beta |
Standard Error |
Odds Ratio |
95% LCI |
95% UCI |
P-value |
| Normocapnia |
1.40 |
0.62 |
4.07 |
1.20 |
13.78 |
0.02 |
| Pulmonary disease |
-0.84 |
0.64 |
0.43 |
0.12 |
1.52 |
0.19 |
| Variable |
Beta |
Standard Error |
Odds Ratio |
95% LCI |
95% UCI |
P-value |
| Normocapnia |
1.41 |
0.62 |
4.11 |
1.21 |
13.93 |
0.02 |
| Therapeutic hypothermia | -0.44 | 0.54 | 0.64 | 0.22 | 1.86 | 0.42 |
aDefined as systolic blood pressure < 100 mmHg or vasopressor support required to maintain systolic blood pressure > 100 mmHg during the first 24 hours after return of spontaneous circulation; bDefined as a base deficit ≤ -6 during the first 24 hours after return of spontaneous circulation; CPR, cardiopulmonary resuscitation; LCI, lower confidence interval; PEA, pulseless electrical activity; UCI, upper confidence interval.