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. 2014 Mar 5;7:15. doi: 10.1186/1756-6606-7-15

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Copyright © 2014 Xiang et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Possible interactions among neurexin (Nrxn), neuroligin (Nlgn) and acetylcholinesterase (AChE) at glutamatergic synapses under normal and pathological conditions. Under normal conditions, O-glycosylated β-neurexins are primarily associated with neuroligin-1, forming trans-synaptic junctions and inducing pre- and post-synaptic maturation. Under pathological conditions, N-glycosylated AChE increases (or O-glycosylation of β-neurexins decreases), allowing more interactions between N-glycosylated AChE and non-O-glycosylated β-neurexins and a consequent loss of glutamatergic synapses and intracellular accumulation of post-synaptic proteins such as postsynaptic density protein 95 (PSD-95) and the glutamate receptor subunits GluN1a (NR1a) and GluA2 (GluR2).