Table 11.
GSTM1 deletion polymorphism in association with CF clinical variables as distributed by CFTR mutation
| Variable |
Without taking
CFTR
mutation into account |
No
CFTR
mutations identified |
No
CFTR
mutations identified with PI |
One identified
CFTR
mutation |
One identified
CFTR
mutation with PI |
Two identified
CFTR
mutations |
||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| p -value | p -corrected | p -value | p -corrected | p -value | p -corrected | p -value | p -corrected | p -value | p -corrected | p -value | p -corrected | |
| Gendera |
0.171 |
0.684 |
0.764 |
1 |
0.075 |
0.300 |
0.267 |
1 |
0.537 |
1 |
0.110 |
0.440 |
| Agea |
1 |
1 |
0.498 |
1 |
0.736 |
1 |
0.579 |
1 |
1 |
1 |
1 |
1 |
| Onset of symptomsa |
0.268 |
1 |
0.459 |
1 |
0.721 |
1 |
1 |
1 |
1 |
1 |
0.629 |
1 |
| Onset of pulmonary diseasea |
0.424 |
1 |
0.068 |
0.272 |
1 |
1 |
1 |
1 |
0.742 |
1 |
0.639 |
1 |
| Onset of digestive diseasea |
0.409 |
1 |
0.665 |
1 |
1 |
1 |
1 |
1 |
0.008 |
0.032 |
0.635 |
1 |
| Diagnosisa |
1 |
1 |
0.059 |
0.236 |
0.729 |
1 |
0.149 |
0.596 |
1 |
1 |
1 |
|
| BMIa |
0.462 |
1 |
0.503 |
1 |
0.115 |
0.460 |
0.725 |
1 |
1 |
1 |
0.169 |
0.676 |
| Bhalla scoreb |
0.86 |
1 |
0.11 |
0.44 |
0.059 |
0.236 |
0.050 |
0.200 |
0.692 |
1 |
0.879 |
1 |
| Kanga scoreb |
0.982 |
1 |
0.693 |
1 |
0.367 |
1 |
0.822 |
1 |
0.480 |
1 |
0.784 |
1 |
| Shwachman-Kulczycki scoreb |
0.501 |
1 |
0.449 |
1 |
0.884 |
1 |
0.123 |
0.492 |
0.777 |
1 |
0.568 |
1 |
| Nasal polyposisa |
0.331 |
1 |
0.136 |
0.544 |
0.610 |
1 |
1 |
1 |
0.407 |
1 |
0.765 |
1 |
| Diabetes mellitusa |
0.560 |
1 |
1 |
1 |
1 |
1 |
0.703 |
1 |
1 |
1 |
0.169 |
0.676 |
| Osteoporosisa |
0.217 |
0.868 |
0.435 |
1 |
0.377 |
1 |
0.173 |
|
0.633 |
1 |
1 |
1 |
| Meconium ileus |
1 |
1 |
1 |
1 |
0.640 |
1 |
0.726 |
1 |
1 |
1 |
0.776 |
1 |
| Pancreatic insufficiencya |
1 |
1 |
0.765 |
1 |
- |
- |
1 |
1 |
- |
- |
1 |
1 |
| SpO2b |
0.187 |
0.748 |
0.012 |
0.048 |
0.500 |
1 |
0.780 |
1 |
0.652 |
1 |
0.645 |
1 |
| FVC(%)b |
0.990 |
1 |
0.741 |
1 |
0.020 |
0.08 |
0.538 |
1 |
0.307 |
1 |
0.967 |
1 |
| FEV1(%)b |
0.827 |
1 |
0.623 |
1 |
0.030 |
0.012 |
0.786 |
1 |
0.972 |
1 |
0.943 |
1 |
| FEV1/FVCb |
0.915 |
1 |
0.749 |
1 |
0.532 |
1 |
0.918 |
1 |
0.244 |
0.976 |
0.597 |
1 |
| FEF25–75%b |
0.853 |
1 |
0.718 |
1 |
0.197 |
0.788 |
0.819 |
1 |
0.255 |
1 |
0.847 |
1 |
| First P. aeruginosaa |
0.724 |
1 |
1 |
1 |
0.473 |
1 |
0.056 |
0.224 |
1 |
1 |
0.312 |
1 |
|
P. aeruginosa mucoida |
0.092 |
0.368 |
0.729 |
1 |
0.289 |
1 |
1 |
1 |
0.541 |
1 |
0.107 |
0.428 |
|
P. aeruginosa no mucoida |
0.879 |
1 |
0.754 |
1 |
0292 |
1 |
0.776 |
1 |
1 |
1 |
0.629 |
1 |
|
A. xylosoxidans
a
|
0.619 |
1 |
0.537 |
1 |
1 |
1 |
0.35 |
1 |
0.511 |
1 |
0.52 |
1 |
|
S. aureus
a
|
0.362 |
1 |
0.175 |
0.700 |
0.391 |
1 |
1 |
1 |
1 |
1 |
0.776 |
1 |
| B. cepacia a | 0.371 | 1 | 0.116 | 0.464 | 0.313 | 1 | 0.703 | 1 | 1 | 1 | 1 | 1 |
aFisher’s exact test used for categorical variables; bStudent’s t-test used for numerical variables. P-values < 0.05 denote clinical association (bold).
CFTR, Cystic fibrosis transmembrane regulator; GSTM1, Glutathione S-transferase mu 1; PI, Pancreatic insufficiency; BMI, Body mass index; SpO2, Hemoglobin oxygen saturation in the blood; FVC, Forced vital capacity; FEV1, Forced expiratory volume in the first second; FEF, Forced expiratory flow between 25 and 75% of vital capacity.