Table 5.
GCLC-129C > T and GCLC-3506A > G haplotype polymorphisms in modifier genes associated with categorical variables of cystic fibrosis severity
|
CFTR
group |
PI taking into account |
Haplotype |
Genotype |
Variable |
pc |
OR |
CI (5–95%) |
||
|---|---|---|---|---|---|---|---|---|---|
|
AX | |||||||||
| Presence | Absence | Total | |||||||
| Two mutation identified |
No |
GCLC-129C > T + GCLC-3506A > G |
CC + AA |
10 |
26 |
36 |
|
17.9 |
2.781-411.6 |
| CC + (AG or GG) |
1 |
30 |
31 |
0.024 |
0.149 |
0.007-0.959 |
|||
| (CT or TT) + GG |
0 |
13 |
13 |
|
- |
- |
|||
| TT + GG | 0 | 5 | 5 | - | - | ||||
Statistical analysis was performed by χ2 test. CFTR, Cystic fibrosis transmembrane regulator; GCLC, Glutamate-cysteine ligase catalytic subunit; PI, Pancreatic insufficiency; AX, Achromobacter xylosoxidans; pc, P-value corrected by Bonferroni test; OR, Odds ratio; CI, Confidence interval.