Table 8.
GCLC-129C > T polymorphism associated with CF clinical variables as distributed by CFTR mutation
| Variable |
Without taking
CFTR
mutation into account |
No
CFTR
mutations identified |
No
CFTR
mutations identified with PI |
One identified
CFTR
mutation |
One identified
CFTR
mutation with PI |
Two identified
CFTR
mutations |
||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| p -value | p -corrected | p -value | p -corrected | p -value | p -corrected | p -value | p -corrected | p -value | p -corrected | p -value | p -corrected | |
| Gendera |
0.577 |
1 |
1 |
1 |
1 |
1 |
0.024 |
0.096 |
0.698 |
1 |
0.418 |
1 |
| Agea |
0.348 |
1 |
1 |
1 |
0.667 |
1 |
1 |
1 |
1 |
1 |
0.249 |
0.996 |
| Onset of symptomsa |
1 |
1 |
0.165 |
0.660 |
0.401 |
1 |
1 |
1 |
1 |
1 |
0.392 |
1 |
| Onset of pulmonary diseasea |
0.162 |
0.648 |
1 |
1 |
1 |
1 |
0.409 |
1 |
0.685 |
1 |
0.168 |
0.672 |
| Onset of digestive diseasea |
1 |
1 |
0.142 |
0.568 |
0.354 |
1 |
0.710 |
1 |
0.650 |
1 |
0.583 |
1 |
| Diagnosisa |
1 |
1 |
1 |
1 |
0.405 |
1 |
0.715 |
1 |
0.412 |
1 |
0.764 |
1 |
| BMIa |
1 |
1 |
0.414 |
1 |
0.559 |
1 |
0.331 |
1 |
1 |
1 |
1 |
1 |
| Bhalla scoreb |
0.626 |
1 |
0.47 |
1 |
0.023 |
0.092 |
0.851 |
1 |
0.090 |
0.360 |
0.834 |
1 |
| Kanga scoreb |
0.277 |
1 |
0.45 |
1 |
0.632 |
1 |
0.687 |
1 |
0.625 |
1 |
0.192 |
0.768 |
| Shwachman-Kulczycki scoreb |
0.917 |
1 |
0.532 |
1 |
0.041 |
0.164 |
0.405 |
1 |
0.435 |
1 |
0.767 |
1 |
| Nasal polyposisa |
0.811 |
1 |
0.66 |
1 |
0.555 |
1 |
0.332 |
1 |
0.577 |
1 |
0.066 |
0.264 |
| Diabetes mellitusa |
0.811 |
1 |
1 |
1 |
1 |
1 |
1 |
1 |
0.315 |
1 |
0.505 |
1 |
| Osteoporosisa |
0.306 |
1 |
1 |
1 |
0.299 |
1 |
0.353 |
1 |
1 |
1 |
0.238 |
0.952 |
| Meconium ileus |
0.792 |
1 |
1 |
1 |
0.576 |
1 |
0.651 |
1 |
0.147 |
0.588 |
0.727 |
1 |
| Pancreatic insufficiencya |
0.063 |
0.252 |
0.267 |
1 |
- |
- |
0.328 |
1 |
|
|
1 |
1 |
| SpO2b |
0.384 |
1 |
0.296 |
1 |
0.078 |
0.312 |
0.124 |
0.496 |
0.864 |
1 |
0.597 |
1 |
| FVC(%)b |
0.822 |
1 |
0.828 |
1 |
0.127 |
0.508 |
0.922 |
1 |
0.506 |
1 |
0.597 |
1 |
| FEV1(%)b |
0.598 |
1 |
0.310 |
1 |
0.160 |
0.640 |
0.983 |
1 |
0.510 |
1 |
0.820 |
1 |
| FEV1/FVCb |
1 |
1 |
0.109 |
0.436 |
0.386 |
1 |
0.873 |
1 |
0.820 |
1 |
0.170 |
0.680 |
| FEF25–75%b |
0.448 |
1 |
0.044 |
0.176 |
1 |
1 |
0.982 |
1 |
0.767 |
1 |
0.537 |
1 |
| First P. aeruginosaa |
1 |
1 |
1 |
1 |
0.691 |
1 |
0.695 |
1 |
0.361 |
1 |
1 |
1 |
|
P. aeruginosa mucoida |
0.133 |
0.532 |
1 |
1 |
0.689 |
1 |
0.011 |
0.044 |
0.427 |
1 |
1 |
1 |
|
P. aeruginosa no mucoida |
1 |
1 |
1 |
1 |
1 |
1 |
0.266 |
1 |
0.680 |
1 |
0.391 |
1 |
|
A. xylosoxidansa |
0.534 |
1 |
1 |
1 |
1 |
1 |
1 |
1 |
1 |
1 |
1 |
1 |
|
S. aureusa |
0.261 |
1 |
0.093 |
0.372 |
1 |
1 |
1 |
1 |
1 |
1 |
1 |
1 |
| B. cepaciaa | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0.318 | 1 | 1 | 1 |
aFisher’s exact test used for categorical variables; bStudent’s t-test used for numerical variables. P-values < 0.05 denote clinical association (bold).
CFTR, Cystic fibrosis transmembrane regulator; PI, Pancreatic insufficiency; GCLC, Glutamate cysteine ligase catalytic subunit; BMI, Body mass index; SpO2, Hemoglobin oxygen saturation in the blood; FVC, Forced vital capacity; FEV1, Forced expiratory volume in the first second; FEF, Forced expiratory flow between 25 and 75% of vital capacity.