Table 9.
GCLC-3506A > G polymorphism in association with CF clinical variables as distributed by CFTR mutation
| Variable |
Without taking
CFTR
mutation into account |
No
CFTR
mutations identified |
No
CFTR
mutations identified with PI |
One identified
CFTR
mutation |
One identified
CFTR
mutation with PI |
Two identified
CFTR
mutations |
||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| p -value | p -corrected | p -value | p -corrected | p -value | p -corrected | p -value | p -corrected | p -value | p -corrected | p -value | p -corrected | |
| Gendera |
0.753 |
1 |
0.532 |
1 |
1 |
1 |
0.149 |
0.596 |
0.510 |
1 |
0.824 |
1 |
| Agea |
0.057 |
0.228 |
0.710 |
1 |
0.245 |
0.980 |
0.541 |
1 |
1 |
1 |
0.339 |
1 |
| Onset of symptomsa |
1 |
1 |
1 |
1 |
0.420 |
1 |
0.731 |
1 |
0.078 |
0.312 |
0.812 |
1 |
| Onset of pulmonary diseasea |
0.507 |
1 |
1 |
1 |
0.152 |
0.608 |
0.727 |
1 |
0.302 |
1 |
0.816 |
1 |
| Onset of digestive diseasea |
0.865 |
1 |
0.646 |
1 |
0.408 |
1 |
1 |
1 |
0.158 |
0.632 |
1 |
1 |
| Diagnosisa |
0.335 |
1 |
0.419 |
1 |
1 |
1 |
0.330 |
1 |
1 |
1 |
1 |
1 |
| BMIa |
1 |
1 |
1 |
1 |
0.281 |
1 |
0.704 |
1 |
0.709 |
1 |
0.785 |
1 |
| Bhalla scoreb |
0.35 |
1 |
0.830 |
1 |
0.468 |
1 |
0.169 |
0.676 |
0.833 |
1 |
0.495 |
1 |
| Kanga scoreb |
0.011 |
0.044 |
0.734 |
1 |
0.788 |
|
0.067 |
0.268 |
0.588 |
1 |
0.027 |
0.108 |
| Shwachman-Kulczycki scoreb |
0.091 |
0.364 |
0.725 |
1 |
0.223 |
0.892 |
0.034 |
0.136 |
0.545 |
1 |
0.159 |
0.636 |
| Nasal polyposisa |
0.688 |
1 |
0.251 |
1 |
0.555 |
1 |
0.692 |
1 |
1 |
1 |
0.083 |
0.332 |
| Diabetes mellitusa |
0.688 |
1 |
1 |
1 |
1 |
1 |
0.419 |
1 |
0.217 |
0.868 |
1 |
1 |
| Osteoporosisa |
0.133 |
0.532 |
1 |
1 |
0.068 |
0.272 |
0.25 |
1 |
0.630 |
1 |
0.335 |
|
| Meconium ileus |
1 |
1 |
1 |
1 |
0.304 |
1 |
1 |
1 |
0.417 |
1 |
1 |
1 |
| Pancreatic insufficiencya |
0.698 |
1 |
0.180 |
0.720 |
- |
- |
0.376 |
1 |
- |
- |
1 |
1 |
| SpO2b |
0.033 |
0.132 |
0.234 |
0.936 |
0.142 |
0.568 |
0.548 |
1 |
0.134 |
0.536 |
0.149 |
0.596 |
| FVC(%)b |
0.412 |
1 |
0.944 |
1 |
0.061 |
0.244 |
0.036 |
0.144 |
0.755 |
1 |
0.955 |
1 |
| FEV1(%)b |
0.166 |
0.664 |
0.877 |
1 |
0.094 |
0.376 |
0.030 |
0.120 |
0.381 |
1 |
0.577 |
1 |
| FEV1/FVCb |
0.054 |
0.216 |
0.912 |
1 |
0.403 |
1 |
0.050 |
0.200 |
0.247 |
0.988 |
0.111 |
|
| FEF25–75%b |
0.061 |
0.244 |
0.934 |
1 |
0.177 |
0.708 |
0.029 |
0.116 |
0.577 |
1 |
0.272 |
1 |
| First P. aeruginosaa |
0.350 |
1 |
0.453 |
1 |
0.433 |
1 |
0.716 |
1 |
0.015 |
0.060 |
0.799 |
1 |
|
P. aeruginosa mucoida |
0.152 |
0.608 |
1 |
1 |
0.443 |
1 |
0.064 |
0.256 |
0.178 |
0.712 |
0.371 |
1 |
|
P. aeruginosa no mucoida |
0.057 |
0.228 |
1 |
1 |
0.243 |
0.972 |
0.003 |
0.012 |
0.023 |
0.092 |
0.351 |
1 |
|
A. xylosoxidansa |
0.187 |
0.748 |
0.066 |
|
0.044 |
0.176 |
0.565 |
1 |
1 |
1 |
0.343 |
1 |
|
S. aureusa |
0.849 |
1 |
0.708 |
1 |
1 |
1 |
0.376 |
1 |
0.024 |
0.096 |
0.394 |
1 |
| B. cepaciaa | 0.246 | 0.984 | 1 | 1 | 1 | 1 | 0.471 | 1 | 0.082 | 0.328 | 0.394 | 1 |
aFisher’s exact test used for categorical variables; bStudent’s t-test used for numerical variables. P-values < 0.05 denote clinical association (bold).
CFTR, Cystic fibrosis transmembrane regulator; GCLC, Glutamate cysteine ligase catalytic subunit; PI, Pancreatic insufficiency; BMI, Body mass index; SpO2, Hemoglobin oxygen saturation in the blood; FVC, Forced vital capacity; FEV1, Forced expiratory volume in the first second; FEF, Forced expiratory flow between 25 and 75% of vital capacity.