Table 2.
Treatment response - intention to treat analyses
|
Response variables |
Parameter |
Unadjusted |
Adjusted |
||||||
|---|---|---|---|---|---|---|---|---|---|
| |
|
Estimate |
Sig. |
95% CI |
Estimate |
Sig. |
95% CI |
||
| Lower bound | Upper bound | Lower bound | Upper bound | ||||||
| AUDIT |
6 months |
−1.95 |
0.197 |
−4.94 |
1.03 |
−1.96 |
0.195 |
−4.94 |
1.02 |
| 12 months |
−3.11 |
0.034 |
−5.97 |
−0.25 |
−3.10 |
0.034 |
−5.96 |
−0.23 |
|
| IG*6 m |
−2.72 |
0.115 |
−6.10 |
0.67 |
−2.63 |
0.139 |
−6.12 |
0.86 |
|
| IG*12 m |
−2.26 |
0.181 |
−5.59 |
1.06 |
−2.18 |
0.209 |
−5.61 |
1.23 |
|
| DUDIT |
6 months |
−1.36 |
0.459 |
−4.99 |
2.27 |
−1.30 |
0.478 |
−4.92 |
2.32 |
| 12 months |
−4.50 |
0.011 |
−7.97 |
−1.03 |
−4.50 |
0.011 |
−7.97 |
−1.04 |
|
| IG*6 m |
−0.39 |
0.942 |
−13.61 |
12.83 |
−1.49 |
0.819 |
−17.30 |
14.32 |
|
| IG*12 m |
0.74 |
0.891 |
−12.48 |
13.96 |
−0.29 |
0.964 |
−16.11 |
15.52 |
|
| SCL-90-anxiety |
6 months |
−0.16 |
0.319 |
−0.48 |
0.16 |
−0.16 |
0.327 |
−0.48 |
0.16 |
| 12 months |
−0.21 |
0.191 |
−0.52 |
0.11 |
−0.21 |
0.194 |
−0.52 |
0.11 |
|
| IG*6 m |
0.21 |
0.491 |
−0.51 |
0.92 |
0.20 |
0.548 |
−0.58 |
0.97 |
|
| IG*12 m |
0.12 |
0.698 |
−0.60 |
0.83 |
0.11 |
0.744 |
−0.67 |
0.88 |
|
| SCL-90-depres-sion |
6 months |
−0.20 |
0.347 |
−0.61 |
0.22 |
−0.19 |
0.374 |
−0.60 |
0.23 |
| 12 months |
−0.37 |
0.074 |
0.77 |
0.04 |
−0.36 |
0.081 |
−0.76 |
0.05 |
|
| IG*6 m |
0.18 |
0.576 |
−0.54 |
0.90 |
0.32 |
0.437 |
−0.60 |
1.24 |
|
| IG*12 m |
0.11 |
0.744 |
−0.61 |
0.82 |
0.25 |
0.546 |
−0.67 |
1.16 |
|
| SCL-90-GSI |
6 months |
−0.19 |
0.185 |
−0.47 |
0.09 |
−0.18 |
0.194 |
−0.46 |
0.10 |
| 12 months |
−0.16 |
0.259 |
−0.43 |
0.12 |
−0.15 |
0.266 |
−0.43 |
0.12 |
|
| IG*6 m |
0.26 |
0.350 |
−0.35 |
0.88 |
0.27 |
0.400 |
−0.45 |
0.99 |
|
| IG*12 m |
0.03 |
0.911 |
−0.58 |
0.64 |
0.05 |
0.884 |
−0.67 |
0.76 |
|
| ASI-alcohol |
6 months |
−5.97 |
0.002 |
−9.63 |
−2.31 |
−5.88 |
0.002 |
−9.55 |
−2.21 |
| 12 months |
−4.10 |
0.022 |
−7.62 |
−0.59 |
−3.95 |
0.029 |
−7.48 |
−0.42 |
|
| IG*6 m |
−0.55 |
0.787 |
−4.53 |
3.44 |
2.47 |
0.210 |
−1.41 |
6.36 |
|
| IG*12 m |
−2.73 |
0.170 |
−6.65 |
1.18 |
0.12 |
0.951 |
−3.67 |
3.90 |
|
| ASI-Illegal substan-ces |
6 months |
−5.59 |
0.141 |
−13.07 |
1.88 |
−5.56 |
0.143 |
−13.03 |
1.90 |
| 12 months |
−6.39 |
0.091 |
−13.82 |
1.04 |
−6.45 |
0.088 |
−13.87 |
0.97 |
|
| IG*6 m |
10.02 |
0.368 |
−15.36 |
35.39 |
9.98 |
0.364 |
−15.10 |
35.06 |
|
| IG*12 m |
8.77 |
0.426 |
−16.60 |
34.13 |
8.86 |
0.416 |
−16.22 |
33.93 |
|
| SATS-R | 6 months |
1.42 |
0.001 |
0.57 |
2.27 |
1.41 |
0.001 |
0.56 |
2.26 |
| 12 months |
2.10 |
<0.001 |
1.27 |
2.93 |
2.09 |
<0.001 |
1.25 |
2.92 |
|
| IG*6 m |
1.59 |
0.070 |
−0.16 |
3.35 |
1.44 |
0.085 |
−0.25 |
3.12 |
|
| IG*12 m | 1.89 | 0.038 | 0.14 | 3.65 | 1.76 | 0.043 | 0.08 | 3.44 | |
Examining differences between the Intervention Group and the Control Group in regard to treatment response - Intention to treat analyses.
6 months = The change of the Control group between baseline and 6 months.
12 months = The change of the Control group between baseline and 12 months.
IG*6 m = The additional change of the Intervention group between baseline and 6 months compared to the Control Group.
IG*12 m = The additional change of the Intervention group between baseline and 12 months compared to the Control Group.
AUDIT = The Alcohol Use Disorder Identification Test, DUDIT = The Drug Use Disorder Identification Test, SCL-90-Anxiety = The Symptom Check List 90 anxiety sum score, SCL-90-Depression = The Symptom Check List 90 depression sum score, SCL-90-GSI = The Symptom Check List 90 Global Severity Index sum score, ASI-Alcohol = The European Addiction Severity Index, number of days using alcohol on a regular basis during the last 30 days, ASI-Illegal substances = The European Addiction Severity Index, number of days using any illegal substances during the last 30 days, SATS-R = The Substance Abuse Treatment Scale, revised.
Statistical significant values are written in bold types, a 5% alfa-level is used.
A linear multilevel model is used. The different response variables are modelled as a function of group and time. The clustering in the data is accounted for by a random intercept at patient level and at centre level. The primary target of analysis was the interaction between group and time. The analyses where adjusted for by the following covariates: Age, Gender, Living alone, Having his/her own apartment and Having compulsory school only. During the adjusted analyses a non-restricted Log likelihood was used. In the final models, the restricted Log Likelihood was used.