Table 2. Uptake by subdivisions of age and risk.
| Age (years) | Lifetime risk 17–25% | Lifetime risk 26–39% | Lifetime risk 40–50% not BRCA | BRCA negativea | BRCA untesteda | Lifetime risk 51–85% (BRCA1/2 or TP53) | Total |
|---|---|---|---|---|---|---|---|
| 33–35 |
2/40 |
8/63 |
0/26 |
0/4 |
0/17 |
0/11 |
11/161 (6.8%) |
| 36–38 |
9/78 |
8/103 |
6/39 |
0/4 |
0/13 |
1/13 |
24/250 (9.6%) |
| 39–40 |
6/52 |
10/95 |
4/31 |
0/9 |
0/9 |
0/5 |
20/201 (10%) |
| 41–43 |
4/87 |
22/139 |
10/58 |
2/16 |
1/14 |
0/16 |
41/330 (12.4%) |
| >43 |
11/101 |
21/151 |
8/46 |
3/22 |
0/9 |
0/8 |
42/337 (12.5%) |
| Total | 32/358 (9.2%) | 69/551 (12.5%) | 28/200 (14%) | 5/55 (9%) | 1/62 (1.7%) | 1b/53 (1.9%) | 136/1279 (10.6%) |
a
BRCA (Breast Cancer 1 or 2, early onset gene mutation) negative refers to women who have known BRCA mutations in their family, but have personally tested negative for their familial mutation. BRCA untested represents women who have known BRCA mutations within the family but have not been tested themselves, thus are at a potential 51–85% risk.
b
TP53 mutation carrier.