Table 1. Clinicopathological parameters of the seven breast cancer biological classes.

	Biological class
Parameter	Luminal A (no=370)	Luminal N (no=146)	Luminal B (no=123)	Basal p53 altered (no=126)	Basal p53 normal (no=87)	HER2+/ER+ (no=60)	HER2+/ER− (no=85)	Cramer's V (Friendly, 2000) (P-value)
	No (%)	No (%)	No (%)	No (%)	No (%)	No (%)	No (%)
Size
<15 mm	106 (28.6)	45 (30.8)	27 (22.0)	15 (11.9)	10 (11.5)	6 (10.0)	10 (11.8)	0.199 (<0.01)
⩾15 mm	264 (71.4)	101 (69.2)	95 (77.2)	111 (88.1)	77 (88.5)	54 (90.0)	75 (88.2)
Grade
1	79 (21.4)	41 (28.1)	20 (16.3)	1 (0.8)	0 (0)	1 (1.7)	1 (1.2)	0.405
2	160 (43.2)	80 (54.8)	48 (39.0)	4 (3.2)	8 (9.2)	13 (21.7)	10 (11.8)	(<0.01)
3	131 (35.4)	25 (17.1)	54 (43.9)	121 (96.0)	79 (90.8)	46 (76.6)	74 (87.0)
LN stage
1	227 (61.4)	100 (68.5)	69 (56.1)	82 (65.1)	56 (64.4)	29 (48.3)	38 (44.7)	0.116 (<0.01)
2	120 (32.4)	37 (25.3)	37 (30.1)	33 (26.2)	24 (27.6)	25 (41.7)	33 (38.8)
3	22 (5.9)	9 (6.2)	15 (12.2)	11 (8.7)	7 (8.0)	6 (10.0)	14 (16.5)
NPI
Excellent	54 (14.6)	29 (19.9)	14 (11.4)	0 (0)	0 (0)	1 (1.7)	1 (1.2)	0.203
Good	93 (25.1)	49 (33.6)	21 (17.1)	2 (1.6)	5 (5.7)	5 (8.3)	4 (4.7)	(<0.01)
Moderate 1	103 (27.8)	34 (23.3)	30 (24.4)	50 939.7)	22 (25.3)	18 (30.0)	24 (28.2)
Moderate 2	70 (18.9)	24 (16.4)	35 (28.5)	45 (35.7)	37 (42.5)	18 (30.0)	26 (30.6)
Poor	39 (10.5)	8 (5.5)	15 (12.2)	20 (15.9)	21 (24.1)	13 (21.7)	19 (22.4)
Very poor	8 (2.2)	2 (1.4)	5 (4.1)	7 (5.6)	1 (1.1)	4 (6.7)	9 (10.6)
Chemotherapy
No	319 (90.1)	128 (90.8)	111 (94.1)	59 (50)	42 (52.5)	45 (78.9)	47 (58)	0.201 (<0.01)
Yes	35 (9.9)	13 (9.2)	7 (5.9)	59 (50)	38 (47.5)	12 (21.1)	34 (42)
Hormone therapy
No	185 (52.1)	90 (62.9)	44 (37.6)	105 (84.6)	60 (75)	24(40)	66 (77.6)	0.362 (<0.01)
Yes	170 (47.9)	53 (37.1)	73 (62.4)	21 (15.4)	20 (25)	36 (60)	19 (22.4)

Abbreviation: LN=lymph node (stage 1=negative LN, stage 2=1–3 positive LN, stage 3=⩾4 positive LN).