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. 2014 Mar 4;110(7):1855–1861. doi: 10.1038/bjc.2014.43

Table 2. Hazard ratios for melanoma, squamous cell carcinoma, and basal cell carcinoma according to cumulative UV flux.

  No. of cases (%) Age-adjusted HR (95%CI) Multivariable HR (95%CI)a
Melanoma (n=634 cases)
UV flux Q1b 88 (14) 0.66 (0.30, 1.47) 0.85 (0.36, 2.01)
UV flux Q2 130 (21) 1.07 (0.58, 1.96) 1.32 (0.68, 2.55)
UV flux Q3 112 (18) 0.89 (0.56, 1.41) 1.02 (0.63, 1.67)
UV flux Q4 129 (20) 1.01 (0.74, 1.38) 1.07 (0.78, 1.47)
UV flux Q5 175 (28) 1.00 1.00
P for trend 0.68 0.77
Per 200 × 10−4 RB units increasec

1.004 (0.966, 1.044)
0.979 (0.933, 1.028)
Squamous cell carcinoma (n=1065 cases)
UV flux Q1b 7 (1) 0.04 (0.01, 0.29) 0.05 (0.01, 0.35)
UV flux Q2 69 (6) 0.29 (0.17, 0.48) 0.34 (0.20, 0.59)
UV flux Q3 162 (15) 0.51 (0.37, 0.69) 0.57 (0.40, 0.79)
UV flux Q4 272 (26) 0.70 (0.57, 0.85) 0.74 (0.60, 0.91)
UV flux Q5 555 (52) 1.00 1.00
P for trend <0.0001 <0.0001
Per 200 × 10−4 RB units increasec

1.069 (1.046, 1.092)
1.072 (1.041, 1.103)
Basal cell carcinoma (n=15 159 cases)
UV flux Q1b 152 (1) 0.41 (0.33, 0.52) 0.47 (0.37, 0.59)
UV flux Q2 2640 (17) 0.40 (0.36, 0.44) 0.45 (0.40, 0.51)
UV flux Q3 3505 (23) 0.59 (0.54, 0.64) 0.64 (0.58, 0.70)
UV flux Q4 3819 (25) 0.81 (0.76, 0.85) 0.84 (0.79, 0.89)
UV flux Q5 5043 (33) 1.00 1.00
P for trend <0.0001 <0.0001
Per 200 × 10−4 RB units increasec 1.052 (1.045, 1.059) 1.043 (1.034, 1.052)

Abbreviations: CI=confidence interval; HR=hazard ratio; UV=ultraviolet.

a

Multivariable analyses adjusted for age, susceptibility to burn, ability to tan, natural hair colour at age 20, number of moles on left arm, family history of melanoma, severe sunburn counts, UV indices at state of residence at birth, 15 and 30 years of age, physical activity level, and rotating night shift.

b

UV flux quintiles: Q1=200–656, Q2=678–1294, Q3=1296–1872, Q4=1874–2614, and Q5=2616–5392 × 10−4 RB units, respectively.

c

Cumulative UV flux was modelled as a continuous variable in the models.