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. 2014 Feb 13;110(7):1834–1840. doi: 10.1038/bjc.2014.63

Table 4. Estimated outcomes and uncertainty intervals expressed as screening activity and undesired outcomes per lung cancer death prevented, stratified by incidence of target population, screening frequency and benefit estimate (ITT or PP).

Screening frequency, benefit estimate Outcome per death prevented UKLS incidence NLST incidence
Annual, ITT
Persons screened for 10 years
35 (26–103)
82 (61–241)
 
Screening episodes
385 (288–1132)
899 (673–2644)
 
Further investigations
54 (40–159)
126 (94–371)
 
Overdiagnosed cases
0.5 (0.0–0.9)
0.5 (0.0–0.9)
Annual, PP
Persons screened for 10 years
32 (24–94)
73 (55–215)
 
Screening episodes
345 (258–1015)
805 (603–2368)
 
Further investigations
48 (36–141)
113 (85–332)
 
Overdiagnosed cases
0.4 (0.0–0.8)
0.4 (0.0–0.8)
Biennial, ITT
Persons screened for 10 years
44 (33–129)
102 (76–300)
 
Screening episodes
263 (197–774)
613 (459–1803)
 
Further investigations
63 (47–185)
147 (110–432)
 
Overdiagnosed cases
0.6 (0.0–1.0)
0.6 (0.0–1.0)
Biennial, PP
Persons screened for 10 years
38 (28–112)
87 (65–256)
 
Screening episodes
224 (168–659)
525 (393–1544)
 
Further investigations
54 (40–159)
126 (94–371)
  Overdiagnosed cases 0.4 (0.0–0.8) 0.4 (0.0–0.8)

Abbreviations: ITT= intent to treat; NLST=National Lung Screening Trial; PP=per protocol; UKLS=UK Lung Screening.