Table 1. Characteristics at recruitment of cases and controls, Breakthrough Generations Study, United Kingdom.
|
Cases |
Controls |
||
---|---|---|---|---|
Characteristic | No.a | % | No.a | % |
Age at entry (years) | ||||
<60 | 121 | 45.7 | 152 | 44.3 |
60–69 | 130 | 49.1 | 165 | 48.1 |
⩾70 |
14 |
5.3 |
26 |
7.6 |
Year of entry to the study | ||||
<2006 | 132 | 49.8 | 155 | 45.2 |
2006 | 71 | 26.8 | 103 | 30.0 |
2007 | 40 | 15.1 | 55 | 16.0 |
⩾2008 |
22 |
8.3 |
30 |
8.8 |
Days blood sample in post | ||||
0–1 | 216 | 82.1 | 278 | 81.3 |
2 | 23 | 8.8 | 28 | 8.2 |
⩾3 |
24 |
9.1 |
36 |
10.5 |
Age at mammogram (years) | ||||
<60 | 123 | 46.4 | 146 | 42.7 |
60–69 | 131 | 49.4 | 175 | 51.2 |
⩾70 |
11 |
4.2 |
21 |
6.1 |
Time of mammogram compared with diagnosis or index date | ||||
<1.0 year earlier | 16 | 6.0 | 76 | 22.2 |
1–1.9 years earlier | 39 | 14.7 | 101 | 29.5 |
2–2.9 years earlier | 96 | 36.2 | 103 | 30.1 |
⩾3.0 years earlier |
114 |
43.0 |
62 |
18.1 |
Timing of mammogram compared with blood draw | ||||
2–3 years earlier | 61 | 23.0 | 46 | 13.5 |
1–1.9 years earlier | 57 | 21.5 | 60 | 17.5 |
Within 12 months | 99 | 37.4 | 149 | 43.6 |
1–1.9 years later | 22 | 8.3 | 32 | 9.4 |
⩾2.0 years later |
26 |
9.8 |
55 |
16.1 |
Age at menarche (years) | ||||
<13 | 94 | 39.2 | 143 | 46.4 |
13 | 67 | 27.9 | 74 | 24.0 |
⩾14 |
79 |
32.9 |
91 |
29.6 |
Age at first birth and parity | ||||
Nulliparous | 27 | 10.2 | 36 | 10.5 |
<25 years/1–2 children | 55 | 20.8 | 85 | 24.8 |
<25 years/⩾3 children | 30 | 11.3 | 69 | 20.1 |
25–29 years/1–2 children | 67 | 25.3 | 84 | 24.5 |
25–29 years/⩾3 children | 39 | 14.7 | 29 | 8.5 |
⩾30 years/1–4 children |
47 |
17.7 |
40 |
11.7 |
Age at menopause (years) | ||||
<50 | 51 | 28.7 | 81 | 35.7 |
50–54 | 99 | 55.6 | 123 | 54.2 |
⩾55 |
28 |
15.7 |
23 |
10.1 |
Former use of postmenopausal hormone therapy (years) | ||||
Never | 144 | 56.7 | 160 | 50.2 |
<5 | 32 | 12.6 | 51 | 16.0 |
5–9 | 45 | 17.7 | 56 | 17.6 |
⩾10 |
33 |
13.0 |
52 |
16.3 |
Body mass index (kg m−2) | ||||
<25.0 | 120 | 45.8 | 162 | 47.8 |
25.0–29.9 | 97 | 37.0 | 128 | 37.8 |
⩾30.0 |
45 |
17.2 |
49 |
14.5 |
Alcohol consumption (g per day) | ||||
None | 52 | 20.0 | 68 | 20.1 |
<5 | 36 | 13.9 | 48 | 14.2 |
5–14 | 88 | 33.9 | 91 | 26.9 |
⩾15 |
84 |
32.3 |
131 |
38.8 |
Family history of breast cancer (yes) |
66 |
24.9 |
57 |
16.6 |
History of benign breast disease (yes) |
93 |
35.4 |
86 |
25.2 |
Total | 265 | 100.0 | 343 | 100.0 |
Numbers do not always add up to the total owing to missing values.