Table 2. Effect of pre-existing diabetes on total mortality in patients with colorectal cancer, by stage.
|
Overall |
Localised or regional stage |
Distant stage |
CVD-specific mortality |
||||||
|---|---|---|---|---|---|---|---|---|---|
| No. of cases/no. of observations | Age-adjusted HR (95% CI) | Multivariate-adjusted HR (95% CI)a | No. of cases/no. of observations | Multivariate-adjusted HR (95% CI)a | No. of Cases/no. of observations | Multivariate-adjusted HR(95% CI)a | No. of Cases/No. of observations | Multivariate-adjusted HR(95% CI)a | |
|
Colorectal cancer | |||||||||
| No diabetes | 21 137/46 400 | Referent | Referent | 13 768/37 608 | Referent | 5753/6679 | Referent | 3456/46 400 | |
| Diabetes | 7545/14 813 | 1.28 (1.25–1.31) | 1.20 (1.17–1.23) | 5309/12 236 | 1.25 (1.21–1.29) | 1710/1921 | 1.12 (1.06–1.18) | 1608/14 813 | 1.38 (1.29–1.46) |
| Diabetes without complications | 5983/12 298 | 1.19 (1.16–1.23) | 1.15 (1.11–1.18) | 4141/10 158 | 1.17 (1.13–1.22) | 1430/1617 | 1.11 (1.04–1.17) | 1199/12 298 | 1.28 (1.20–1.37) |
| Diabetes with complications | 1562/2515 | 1.78 (1.69–1.88) | 1.50 (1.42–1.58) | 1168/2078 | 1.63 (1.53–1.73) | 280/304 | 1.21 (1.07–1.37) | 409/2515 | 1.79 (1.61–1.99) |
|
Colon cancer | |||||||||
| No diabetes | 15 560/34 851 | Referent | Referent | 10 186/28 483 | Referent | 4293/4981 | Referent | 2663/34 851 | |
| Diabetes | 5852/11 632 | 1.29 (1.25–1.33) | 1.20 (1.17–1.24) | 4117/9644 | 1.26 (1.21–1.31) | 1351/1508 | 1.13 (1.06–1.20) | 1259/11 632 | 1.35 (1.26–1.45) |
| Diabetes without complications | 4581/9598 | 1.19 (1.15–1.23) | 1.14 (1.10–1.18) | 3163/7956 | 1.18 (1.13–1.22) | 1123/1265 | 1.10 (1.03–1.18) | 938/9598 | 1.27 (1.18–1.37) |
| Diabetes with complications | 1271/2034 | 1.85 (1.75–1.96) | 1.55 (1.47–1.65) | 954/1688 | 1.70 (1.58–1.82) | 228/243 | 1.28 (1.11–1.46) | 321/2034 | 1.71 (1.52–1.93) |
|
Rectal cancer | |||||||||
| No diabetes | 5577/11 549 | Referent | Referent | 3582/9125 | Referent | 1460/1698 | Referent | 793/11 549 | |
| Diabetes | 1693/3181 | 1.28 (1.21–1.35) | 1.22 (1.15–1.29) | 1192/2592 | 1.23 (1.15–1.32) | 359/413 | 1.10 (0.98–1.24) | 349/3181 | 1.48 (1.30–1.68) |
| Diabetes without complications | 1402/2700 | 1.23 (1.16–1.30) | 1.20 (1.13–1.27) | 978/2202 | 1.19 (1.11–1.28) | 307/352 | 1.13 (0.99–1.28) | 261/2700 | 1.35 (1.17–1.55) |
| Diabetes with complications | 291/481 | 1.61 (1.43–1.81) | 1.35 (1.19–1.52) | 214/390 | 1.45 (1.26–1.68) | 52/61 | 0.98 (0.74–1.31) | 88/481 | 2.18 (1.73–2.74) |
a
In the multivariate models, we adjusted for covariates including age at diagnosis (65–69, 70–74, 75–79, 80–84 and 85+), sex (male, female), race (white, black, American Indian/Alaska Native, Asian or pacific Islander, others), marital status (never married, married, separated, divorced and widowed), grade (grade I – well differentiated; grade II – moderately differentiated; grade III – poorly differentiated and grade IV-undifferentiated) and census tract median income (quartiles) and co-morbidity (0, 1, 2+).