Table 3. Effect of pre-existing diabetes on cancer-specific mortality in patients with colorectal cancer, by stage.
|
Overall |
Localised or regional stage |
Distant stage |
|||||
|---|---|---|---|---|---|---|---|
| No. of cases/No. of observations | Age-adjusted HR (95% CI) | Multivariate-adjusted HR (95% CI)a | No. of cases/No. of observations | Multivariate-adjusted HR (95% CI)a | No. of cases/No. of observations | Multivariate-adjusted HR (95% CI)a | |
|
Colorectal cancer | |||||||
| No diabetes | 12 214/46 400 | Referent | Referent | 6291/37 608 | Referent | 4855/6679 | Referent |
| Diabetes | 3665/14 813 | 0.97 (0.94–1.01) | 0.99 (0.95–1.03) | 1978/12 236 | 0.98 (0.93–1.03) | 1386/1921 | 1.02 (0.96–1.08) |
| Diabetes without complications | 3025/12 298 | 0.96 (0.92–1.001) | 0.98 (0.94–1.02) | 1611/10 158 | 0.97 (0.91–1.02) | 1158/1617 | 1.00 (0.94–1.07) |
| Diabetes with complications | 640/2515 | 1.01 (0.93–1.09) | 1.04 (0.95–1.12) | 367/2078 | 1.07 (0.96–1.19) | 228/304 | 1.13 (0.99–1.29) |
|
Colon cancer | |||||||
| No diabetes | 8806/34 851 | Referent | Referent | 4454/28 483 | Referent | 3638/4981 | Referent |
| Diabetes | 2768/11 632 | 0.97 (0.93–1.01) | 0.99 (0.94–1.03) | 1455/9644 | 0.98 (0.93–1.05) | 1097/1508 | 1.02 (0.95–1.09) |
| Diabetes without complications | 2253/9598 | 0.95 (0.91–1.00) | 0.97 (0.92–1.01) | 1166/7956 | 0.96 (0.90–1.02) | 906/1265 | 0.98 (0.91–1.06) |
| Diabetes with complications | 515/2034 | 1.05 (0.96–1.15) | 1.09 (0.996–1.20) | 289/1688 | 1.12 (0.99–1.26) | 191/243 | 1.22 (1.06–1.42) |
|
Rectal cancer | |||||||
| No diabetes | 3408/11 549 | Referent | Referent | 1837/9125 | Referent | 1217/1698 | Referent |
| Diabetes | 897/3181 | 1.00 (0.93–1.07) | 1.03 (0.95–1.11) | 523/2592 | 1.02 (0.92–1.12) | 289/413 | 1.02 (0.89–1.16) |
| Diabetes without complications | 772/2700 | 1.01 (0.94–1.10) | 1.05 (0.97–1.14) | 445/2202 | 1.02 (0.92–1.13) | 252/352 | 1.05 (0.92–1.21) |
| Diabetes with complications | 125/481 | 0.91 (0.76–1.09) | 0.90 (0.75–1.08) | 78/390 | 0.99 (0.79–1.25) | 37/61 | 0.83 (0.59–1.15) |
a
In the multivariate models, we adjusted for covariates including age at diagnosis (65–69, 70–74, 75–79, 80–84 and 85+), sex (males, females), race/ethnicity (white, black, American Indian/Alaska Native, Asian or pacific Islander, others), marital status (never married, married, separated, divorced and widowed), grade (grade I – well differentiated; grade II – moderately differentiated; grade III – poorly differentiated and grade IV – undifferentiated), census tract median income (quartiles) and co-morbidity (0, 1, 2+).