Table 2. Cox regression multivariate analysis including LRIG1 staining intensity and known prognostic factors for patients with oropharyngeal cancer.
|
Disease-free survival |
Overall survival |
|||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P-value | HR | 95% CI | P-value | |
|
LRIG1 intensity | ||||||
| Absent | 1 | (ref) | 1 | (ref) | ||
| Present |
0.24 |
0.11–0.49 |
<0.0001 |
0.49 |
0.26–0.91 |
0.024 |
|
HPV status | ||||||
| Negative | 1 | (ref) | 1 | (ref) | ||
| Positive |
0.37 |
0.18–0.75 |
0.006 |
0.26 |
0.15–0.43 |
<0.0001 |
|
CD44 intensity | ||||||
| Absent/weak | 1 | (ref) | 1 | (ref) | ||
| Medium/strong |
2.88 |
0.99–8.37 |
0.052 |
2.91 |
1.22–6.94 |
0.016 |
|
Age | ||||||
| >67 years | 1 | (ref) | 1 | (ref) | ||
| 60–67 years | 0.91 | 0.41–2.05 | 0.82 | 0.64 | 0.34–1.21 | 0.17 |
| 54–60 years | 0.58 | 0.23–1.45 | 0.25 | 0.43 | 0.21–0.89 | 0.022 |
| <54 years |
0.30 |
0.085–1.09 |
0.067 |
0.50 |
0.23–1.09 |
0.080 |
|
Stage | ||||||
| I+II | 1 | (ref) | 1 | (ref) | ||
| III+IV |
1.41 |
0.55–3.63 |
0.48 |
2.80 |
1.09–7.18 |
0.033 |
|
Sex | ||||||
| Female | 1 | (ref) | 1 | (ref) | ||
| Male |
1.08 |
0.52–2.20 |
0.84 |
0.61 |
0.33–1.11 |
0.11 |
|
Localisation | ||||||
| Tonsillar SCC | 1 | (ref) | 1 | (ref) | ||
| Base of tongue SCC | 1.06 | 0.20–2.21 | 0.89 | 0.88 | 0.51–1.52 | 0.65 |
Abbreviations: CI=confidence interval; HPV=human papillomavirus; HR=hazards ratio; LRIG1=leucine-rich repeats and immunoglobulin-like domains 1; SCC=squamous cell carcinoma.