Table 3. Cox regression multivariate analysis including the percentage of LRIG1-positive cells and known prognostic factors for patients with oropharyngeal cancer.
|
Disease-free survival |
Overall survival |
|||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P-value | HR | 95% CI | P-value | |
|
LRIG1 expression | ||||||
| 0–25% | 1 | (ref) | 1 | (ref) | ||
| 26–100% |
0.33 |
0.17–0.65 |
0.001 |
0.49 |
0.30–0.82 |
0.006 |
|
HPV status | ||||||
| Negative | 1 | (ref) | 1 | (ref) | ||
| Positive |
0.34 |
0.17–0.69 |
0.003 |
0.27 |
0.16–0.45 |
<0.0001 |
|
CD44 intensity | ||||||
| Absent/weak | 1 | (ref) | 1 | (ref) | ||
| Medium/strong |
2.81 |
0.97–8.15 |
0.057 |
2.96 |
1.24–7.02 |
0.014 |
|
Age | ||||||
| >67 years | 1 | (ref) | 1 | (ref) | ||
| 60–67 years | 1.02 | 0.46–2.27 | 0.96 | 0.67 | 0.37–1.24 | 0.203 |
| 54–60 years | 0.57 | 0.22–1.41 | 0.22 | 0.43 | 0.21–0.88 | 0.020 |
| <54 years |
0.29 |
0.082–1.05 |
0.59 |
0.50 |
0.23–1.09 |
0.082 |
|
Stage | ||||||
| I+II | 1 | (ref) | 1 | (ref) | ||
| III+IV |
1.29 |
0.50–3.33 |
0.59 |
2.6 |
1.02–6.72 |
0.045 |
|
Sex | ||||||
| Female | 1 | (ref) | 1 | (ref) | ||
| Male |
1.05 |
0.51–2.15 |
0.90 |
0.62 |
0.34–1.15 |
0.13 |
|
Localisation | ||||||
| Tonsillar SCC | 1 | (ref) | 1 | (ref) | ||
| Base of tongue SCC | 1.29 | 0.62–2.68 | 0.50 | 0.99 | 0.58–1.71 | 0.98 |
Abbreviations: CI=confidence interval; HPV=human papillomavirus; HR=hazards ratio; LRIG1=leucine-rich repeats and immunoglobulin-like domains 1; SCC=squamous cell carcinoma.