Table 4. Significant prognostic factors in multivariate analyses.

	P-value	RR	95% CI
(A) (included: localisation, grading, Laurén classification, signet ring cell cancer, clinical response, complications, surgical complications, ypTNM, R status, and histopathological regression)
Clinical responsea	0.004	1.53	1.14–2.05
Complicationsa	0.001	0.70	0.57–0.87
ypT categorya	0.002
ypT0	0.009	0.31	0.13–0.75
ypT1	0.039	0.51	0.27–0.97
ypT2	<0.001	0.42	0.26–0.68
ypT3	0.140	0.81	0.61–1.07
ypN categorya	<0.001
ypN0	<0.001	0.45	0.33–0.63
ypN1	0.010	0.65	0.47–0.90
ypN2	0.003	0.66	0.48–0.68
M category	<0.001	0.55	0.42–0.73
R category	0.014
R0	0.018	0.55	0.34–0.91
R1	0.240	0.75	0.47–1.21
(B) (clinical response excluded) (included: localisation, grading, Laurén classification, signet ring cell cancer, complications, surgical complications, ypTNM, R status, and histopathological regression)
Localisationa	0.006
Signet cell type cancera	0.033	1.32	1.02–1.70
Complicationsa	0.004	0.73	0.58–0.90
ypT categorya	<0.001
ypT0	<0.001	0.19	0.08–0.47
ypT1	0.006	0.39	0.20–0.76
ypT2	<0.001	0.38	0.23–0.64
ypT3	0.075	0.73	0.52–1.03
ypN categorya	<0.001
ypN0	<0.001	0.40	0.29–0.56
ypN1	0.001	0.57	0.41–0.79
ypN2	<0.001	0.60	0.45–0.80
M categorya	<0.001	0.53	0.40–0.70
R categorya	0.009
R0	0.004	0.48	0.29–0.79
R1	0.041	0.60	0.37–0.98
(C) (clinical response+localisation excluded) (included: grading, Laurén classification, signet ring cell cancer, complications, surgical complications, ypTNM, R status, and histopathological regression)
Complicationsa	<0.001	0.69	0.56–0.85
ypT categorya	<0.001
ypT0	0.001	0.23	0.10–0.55
ypT1	0.008	0.42	0.23–0.80
ypT2	<0.001	0.40	0.28–0.72
ypT3	0.198	0.84	0.64–1.1
ypN categorya	<0.001
ypN0	<0.001	0.43	0.32–0.59
ypN1	0.003	0.61	0.44–0.85
ypN2	0.002	0.63	0.47–0.84
M categorya	<0.001	0.55	0.42–0.72
R categorya	0.006
R0	0.011	0.53	0.33–0.86
R1	0.212	0.74	0.46–1.19
(D) (R0 completely resected patients) (included: grading, Laurén classification, signet ring cell cancer, clinical response, complications, surgical complications, ypTNM, and histopathological regression)
Surgical complicationsa	0.004	0.68	0.52–0.89
ypT categorya	<0.001
ypT0	0.002	0.25	0.10–0.61
ypT1	0.011	0.40	0.19–0.81
ypT2	<0.001	0.36	0.21–0.63
ypT3	0.318	0.922	0.56–1.21
ypN categorya	<0.001
ypN0	<0.001	0.39	0.27–0.57
ypN1	0.006	0.58	0.39–0.85
ypN2	0.006	0.59	0.41–0.86
M category a	<0.001	0.47	0.33–0.67

Abbreviations: CI=confidence interval; RR=relative risk.

^aConfirmation by Cox backward regression analysis.

Results of Cox forward regression analysis.