Table 1.
Age-related characteristics, bone turnover markers and T-scores at various skeletal sites
| Marker |
Age (years) |
|||||
|---|---|---|---|---|---|---|
| 20–29 ( n = 124) | 30–39 ( n = 141) | 40–49 ( n = 238) | 50–59 ( n = 229) | 60–69 ( n = 133) | ≥70 ( n = 26) | |
|
Height (cm) |
158 ± 5.6b |
157 ± 5.3b |
155 ± 5.1 |
154 ± 4.6 |
151 ± 5.0 |
152 ± 4.6 |
|
Weight (kg) |
50.1 ± 6.5b |
54.3 ± 7.4 |
57.5 ± 8.1 |
56.1 ± 8.5 |
54.5 ± 8.7 |
54.4 ± 9.3 |
|
BMI (kg/m
2
) |
20.2 ± 2.3b |
22.0 ± 2.5b |
23.9 ± 3.0 |
23.7 ± 3.3 |
23.7 ± 3.2 |
23.7 ± 3.7 |
|
MSU-Cr (mmol/L) |
11.4 ± 5.1b |
11.0 ± 5.0b |
8.8 ± 4.7 |
7.7 ± 4.3 |
7.8 ± 4.4 |
8.9 ± 5.2 |
|
BAP (U/L)
a
|
16.0 ± 1.3 |
15.5 ± 1.4 |
22.0 ± 1.5c |
32.1 ± 1.4d |
29.1 ± 1.4 |
25.5 ± 1.4 |
|
OC (μg/L)
a
|
7.3 ± 1.5 |
4.7 ± 1.6 |
5.7 ± 1.8c |
10.6 ± 1.6d |
10.4 ± 1.6 |
10.2 ± 1.4 |
|
sNTX (nmol/L)
a
|
13.9 ± 1.3 |
13.0 ± 1.3 |
13.2 ± 1.5 |
16.2 ± 1.5d |
18.0 ± 1.5 |
19.0 ± 1.3 |
|
sCTX (mg/L)
a
|
3.7 ± 1.4 |
2.4 ± 1.6 |
2.6 ± 1.9 |
4.1 ± 1.6d |
4.1 ± 1.6 |
4.9 ± 1.6 |
|
uNTX (nM BCE/mM Cr)
a
|
33.3 ± 1.6 |
24.6 ± 1.7 |
33.3 ± 2.2c |
60.3 ± 2.2d |
49.8 ± 2.2 |
36.4 ± 1.9 |
|
uCTX (μg/mM Cr)
a
|
167 ± 1.7 |
85.1 ± 3.0 |
117 ± 2.6c |
244 ± 2.2d |
235 ± 2.1 |
193 ± 2.1 |
|
uDPD (nM/mM Cr)
a
|
6.1 ± 1.4 |
4.2 ± 1.8 |
5.0 ± 1.8c |
6.3 ± 1.6d |
6.1 ± 1.7 |
5.9 ± 1.6 |
|
PA T-score |
0.0 ± 0.8 |
0.1 ± 0.9 |
−0.2 ± 1.1 |
−1.2 ± 1.1d |
−2.0 ± 1.0e |
−2.1 ± 1.0e |
|
FN T-score |
−0.1 ± 1.1 |
−0.1 ± 1.2 |
−0.2 ± 1.2 |
−1.1 ± 1.2d |
−2.0 ± 1.0e |
−2.4 ± 1.0e |
| Hip T-score | 0.1 ± 0.9 | 0.1 ± 0.9 | 0.0 ± 1.0 | −0.7 ± 0.9d | −1.5 ± 0.8e | −1.8 ± 1.0e |
Abbreviations: BMI body mass index, MSU Cr-morning second urinary creatinine, BAP bone-specific alkaline phosphatase, OC osteocalcin, sNTX serum cross-linked N-terminal telopeptides of type I collagen (NTX), sCTX serum cross-linked C-terminal telopeptides of type I collagen (CTX), uNTX urinary NTX, uCTX urinary CTX, uDPD urinary deoxypyridinoline, Cr reatinine, BCE bone collagen equivalents, PA posteroanterior spine, FN femoral neck, Hip total hip. aValues are expressed as geometric mean ± SD. bP = 0.005–0.000 compared with various age groups of ≥40 years. cP = 0.032–0.000 compared with the age groups of 30–39 years. dP = 0.025–0.000 compared with the age groups of 30–39 and 40–49 years. eP = 0.000 compared with various age groups of <60 years.