Table 2.
Laboratory measurements
| Valvar (n = 20) | P* value |
CAD/MS group |
|||||
|---|---|---|---|---|---|---|---|
| Control (n = 17) | Simvastatin (n = 20) | Pioglitazone (n = 18) | Pioglitazone + Simvastatin (n = 18) | P** value | |||
|
TG (mg/dL) |
103.1 ± 40.48 |
0.002 |
162.88 ± 55.89 |
152 ± 68.64 |
167.89 ± 61.29 |
110.39 ± 22.1 |
0.011 |
|
LDL-c (mg/dL) |
103.5 ± 29.68 |
0.381 |
123.76 ± 19.13 |
92.45 ± 33.57 |
142 ± 31.15 |
89.06 ± 25.62 |
<0.001 |
|
HDL-c (mg/dL) |
44.1 ± 13.88 |
<0.001 |
34.35 ± 3.9 |
40.25 ± 7.5 |
41.39 ± 8.36 |
41.89 ± 6.33 |
0.006 |
|
Glucose (mg/dL) |
82.95 ± 11.77 |
<0.001 |
101.18 ± 12.34 |
93.2 ± 17.11 |
120.44 ± 23.99* |
144.44 ± 31.89* |
<0.001 |
|
HbA1c (%) |
5.63 ± 0.41 |
0.003 |
5.78 ± 0.49 |
5.59 ± 0.57 |
6.72 ± 1.55 |
6.41 ± 1.16 |
0.004 |
|
Urea (mg/dL) |
17 ± 4.11 |
0.3 |
25 ± 7.5 |
21 ± 3.3 |
31 ± 2.22 |
30 ± 2.24 |
0.011 |
|
Creatinine (mg/dL) |
0.9 ± 0.2 |
0.42 |
1.1 ± 0.8 |
1.0 ± 0.42 |
1.2 ± 0.9 |
1,25 ± 0.7 |
0.01 |
|
hsCRP (mg/L) |
3.89 ± 1.49 |
0.466 |
7.42 ± 1.45 |
1.93 ± 1.59 |
2.97 ± 1.21 |
1.88 ± 0.65 |
<0.001 |
|
IL-6 (pg/mL) |
3.51 ± 0.95 |
0.811 |
5.3 ± 1.06 |
3.29 ± 1.15 |
3.15 ± 1.15 |
2.68 ± 0.69 |
<0.001 |
|
TNF-α (pg/mL) |
14.71 ± 4.06 |
0.317 |
16.58 ± 2.4 |
18.28 ± 10.91 |
7.92 ± 1.03 |
8.65 ± 2.1 |
<0.001 |
|
Leptin (pg/mL) |
3519.75 ± 1997.54 |
<0.001 |
17043.69 ± 2065.78 |
4836.25 ± 1310.68 |
42899.54 ± 9011.58 |
13979.94 ± 1622.5 |
<0.001 |
|
Resistin (ng/mL) |
4.34 ± 1.09 |
<0.001 |
12.1 ± 1.38 |
6.41 ± 0.97 |
5.41 ± 1.32 |
7.41 ± 0.99 |
<0.001 |
|
Adiponectin (mg/mL) |
15280 ± 4389.45 |
<0.001 |
1480.59 ± 426.02 |
4601.85 ± 1044.07 |
6099.38 ± 1227.84 |
7427.43 ± 1229.81 |
<0.001 |
|
MCP-1 (pg/mL) |
73 ± 6.23 |
<0.001 |
341.93 ± 66.16 |
66.48 ± 11.2 |
381.55 ± 69.28 |
325.98 ± 62.07 |
<0.001 |
|
ADMA (μmol/L) |
0.47 ± 0.13 |
0.595 |
0,53 ± 0.14 |
0.47 ± 0.12 |
0.44 ± 0.33 |
0.34 ± 0.11 |
0.05 |
| MMP-9 (ng/mL) | 553.35 ± 157.38 | 0.146 | 577.08 ± 147.01 | 672.65 ± 340.37 | 216.54 ± 32.6 | 362.76 ± 103.57 | <0.001 |
Values are means ± SD. TG = triglyceride; LDL = low-density lipoprotein cholesterol; HDL = high-density lipoprotein cholesterol; HbA1c = hemoglobin A1c. In the Pioglitazone only and Simvastatin + pioglitazone groups, the baseline values of glucose were higher than final values. hsCRP = C-reactive protein IL-6 = interleukin-6; TNF-α = tumoral necrosis factor. P* value = Comparison between non-CAD group and CAD/MS group. P** value = Comparison between CAD/MS groups.