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. 2014 Mar 28;15:42. doi: 10.1186/1471-2156-15-42

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Copyright © 2014 Nair et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Degree of optic nerve degeneration is comparable between CD94 sufficient and deficient mice. To assess the effects of CD94 sufficiency on optic nerve degeneration, we analyzed PPD-stained optic nerve cross sections. For this analysis, CD94 sufficient mice had either a D2 Klrd1^+/+or D2 Klrd1^+/- genotype, while CD94 deficient mice were Klrd1^-/-.A) Distributions of optic nerve damage at 12 mo. B) Representative images from nerves with no glaucoma have a clear axoplasm and darkly stained myelin sheath. Nerves with severe damage have extensive axon loss and glial scarring. CD94 status did not alter glaucomatous optic nerve damage. For each group > 30 eyes were evaluated.