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. 2014 Mar 25;11:56. doi: 10.1186/1742-2094-11-56

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Copyright © 2014 Wang et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Aspirin-induced inhibition of Notch activation and proinflammatory cytokine production. Rats received various aspirin treatments around a 90-minute middle cerebral arterial occlusion (MCAO). The right frontal cortex area 1 was harvested at 24 hours after the MCAO. The cytosol was prepared for Western blotting for Notch intracellular domain (NICD) and ELISA for IL-6 and IL-1β. (A) NICD expression. Top panel shows representative Western blots and bottom panel shows the quantification results. (B) IL-6 results. (C) IL-1β results. Results are the means ± SEM (n = 8). *P < 0.05, compared with sham operated animals; ^P < 0.05, compared with the animals subjected to MCAO only. ASA, acetylsalicylic acid.