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. 2014 Mar 19;10(3):108–114. doi: 10.6026/97320630010108

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© 2014 Biomedical Informatics

This is an open-access article, which permits unrestricted use, distribution, and reproduction in any medium, for non-commercial purposes, provided the original author and source are credited.

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The domain organization of p210^BCR-ABL proteins. The part that is derived from BCR gene is shown in green and the other half that is derived from ABL gene is shown in purple. The structural differences found in the SH₃, SH₂, SH₁ and DNAbinding domains of p210^BCR-ABL are indicated by arrows. Also shown in the figure are oligomerization domain (D/D), actinbinding domain and the positions of Tyr 177 and Tyr 412 [33].