Fig. 4.

EphB4ΔC-EGFP enhances tumor growth in a xenograft model. MDA-MB-435 cells expressing EphB4ΔC-EGFP or EGFP-F and untransfected cells were injected in nude mice, and tumor sizes were measured at the indicated time points. The graphs in A–E show average tumor volumes ± SEM in groups of five to seven mice, except for the untransfected MDA cells shown in C, which were injected in two mice. #, One of the mice in this group was killed before this measurement. (F) Data used for two-way ANOVA analysis, which include one time point (the last time point for which all tumors in each group were still available) for each of the experiments shown in A–E. EphB4ΔC-EGFP increases tumor growth significantly (P < 0.001).