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. 2013 Feb;108(1):13–17. doi: 10.1590/S0074-02762013000100002

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This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Frequency of amino acid substitutions in the non-structural protein 3 (NS3) region of hepatitis C virus (HCV) genotype 1a. The consensus sequence of amino acids is represented in blue. The subscript number at right refers to the position of the amino acid in the protein. Above each amino acid is represented the substitution and its absolute frequency. The highlighted numbers are the catalytic triad (black circles) and the residues linked to zinc (dotted square).