Table 1.

Association results for systemic lupus erythematosus risk variants in IgA nephropathy

Chr	Base Pair	Locus	SNP	Major/Minor Allele	MAF Case/Control (%)	Trend Test P Values	Allele OR (95% CI) by SLE Risk Allelea	Dominant P Values	Recessive P Values	Genotype P Values	SLE Risk Allele OR (Reference)
1	194953541	CFH	rs6677604	G/A	4.10/7.26	8.41×10−6	0.55 (0.42 to 0.72)	3.37×10−5b	1.80×10−2	5.47×10−5	1.19 (41)
1	234106500	LYST	rs9782955	C/T	12.87/10.71	3.31×10−2	0.81 (0.67 to 0.98)	6.31×10−3	0.18	3.15×10−3	1.18 (35)
3	58345217	PXK	rs6445975	T/G	23.79/19.79	2.01×10−3	0.79 (0.68 to 0.92)	3.78×10−3	0.07	9.00×10−3	1.20 (31)
6	32508322	HLA-DRA	rs9501626	C/A	11.39/16.26	4.91×10−6	0.66 (0.55 to 0.79)	4.68×10−6b	0.12	2.60×10−5	1.86 (32)
6	32694832	HLA-DRB1	rs9271366	A/G	12.60/18.65	6.96×10−8	0.63 (0.53 to 0.75)	4.37×10−10b	0.81	3.40×10−10	1.26 (36)
8	11377591	BLK	rs7812879	C/T	26.59/23.23	1.23×10−2	0.83 (0.72 to 0.96)	3.28×10−2	0.05	0.04	1.45 (34)
8	11381089	BLK	rs2254546	G/A	26.63/23.12	9.32×10−3	0.83 (0.72 to 0.95)	2.35×10−2	4.88×10−2	2.96×10−2	1.42 (32)
8	11381382	BLK	rs2736340	T/C	29.94/26.94	3.33×10−2	0.86 (0.75 to 0.99)	7.78×10−2	0.07	0.08	1.35 (36)
22	20247190	UBE2L3	rs131654	T/G	46.48/49.94	2.63×10−2	1.15 (1.02 to 1.30)	0.17	2.38×10−2	0.06	1.28 (34)
22	20269675	UBE2L3	rs5754217	G/T	47.32/43.74	2.11×10−2	1.16 (1.02 to 1.31)	2.36×10−2	0.15	0.06	1.20 (36)

The reported SLE risk alleles are set in boldface. Chr, chromosome; SNP, single-nucleotide polymorphism; MAF, minor allele frequency; OR, odds ratio; 95% CI, 95% confidence interval; SLE, systemic lupus erythematosus.

^aORs were calculated on the basis of SLE risk alleles for comparison. Reported ORs were derived from the references listed.

^bOnly SNPs in CFH and HLA regions could retain statistical significance after multiple correction.