. 2014 Jan 23;9(4):788–797. doi: 10.2215/CJN.01860213

Table 2.

Correlation between genotypes of identified IgA nephropathy–associated single-nucleotide polymorphisms with gene expression in Epstein–Barr virus–transformed lymphoblastoid cell lines from an open database

SNP	Gene	HapMap 3 Unrelated Individuals (P Value)				Children Siblings of British Descent (n=405)
SNP	Gene	CEU (n=165)	CHB (n=137)	JPT (n=113)	YRI (n=203)	Children Siblings of British Descent (n=405)
rs6445961-A	PXK	0.27 (4.10×10⁻³)^a	−0.20	−0.18	0.02	ND
rs6445961-A	PXK	0.27 (4.10×10⁻³)^a	0.07	0.10	0.83	ND
rs2298428-C	UBE2L3	−0.28 (3.30×10⁻³)^a	−0.28 (0.01)^a	−0.43 (5.00×10⁻⁵)^a	–	−0.390 (8.50×10⁻⁵)^a
rs6677604-A	CFH	0.12 (0.22)	0.02 (0.84)	0.26 (0.03)^a	0.11 (0.26)	–
rs9501626-A	HLA-DRA	–	–	–	–	–
rs9270984-G	HLA-DRB1	0.59 (1.00×10⁻¹¹)^a	0.72 (1.30×10⁻¹³)^a	0.68 (1.40×10⁻¹²)^a	0.68 (4.90×10⁻¹⁶)^a	–
rs9271366-G	HLA-DRB1	0.63 (4.70×10⁻¹³)^a	0.74 (3.80×10⁻¹⁵)^a	0.75 (3.10×10⁻¹⁶)^a	0.73 (3.90×10⁻¹⁹)^a	0.878 (4.00×10⁻¹⁷)^a
rs2254546-G	BLK	0.02 (0.82)	−0.43 (8.20×10⁻⁵)^a	−0.51 (1.10×10⁻⁶)^a	−0.06 (0.57)	ND

With the function of each increase of the risk allele, the table depicts the correlation between genotypes and gene expressions. Protective alleles were regarded as reference alleles in the correlation. Pearson correlation coefficients are presented with P values in brackets. CEU, Caucasians living in Utah who were of northern and western European ancestries; CHB, Han Chinese from Beijing, China; JPT, Japanese in Tokyo, Japan; YRI, Yoruba in Ibadan, Nigeria; ND, no data could be derived from the database.

P<0.05.